Early detection and intervention of psychosis in children and adolescents: urgent need for studies
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Psychotic disorders, particularly of the schizophrenia-spectrum, are among the most severe mental diseases. They can lead to delays in the maturation of neuropsychological functions in affected children and adolescents and long-term neuropsychological deficits [1, 2] as well as significant impairments in psychosocial functioning . This makes schizophrenia one of the six leading causes of years lived with disability . To fight the devastating consequences of psychotic disorders, two strategies have been followed with great enthusiasm and hope over the last 15 years.
One strategy is to detect the disorder as early as possible, i.e., to reduce the duration of untreated psychosis and, consequently, to adequately treat the disorder as soon as possible with an early and specialized intervention. Notably, it was assumed for a long time that an adolescent onset of psychosis (before age 18, EOP) is associated with worse outcomes compared to adult-onset psychosis (AOP; ). However, two recent studies comparing EOP (age 14–17) with AOP (age 18–30) did not support this assumption. They indicated that EOP when also treated in an early psychosis, prevention and intervention centre have similar short-term  and similar or even better long-term outcomes . Most recently, an independent comparative population based study conducted in a different centre confirmed these findings . It still remains to be shown whether specialized early detection and intervention indeed causes the similar or even better outcomes of EOP. Despite the face validity of early intervention, it is not yet clear for patients with AOP that early intervention is superior to treatment-as-usual for patients with AOP. A recent Cochrane review concluded that there is some support for the superior effectiveness of early intervention, but that further studies are desirable, and that it is questionable whether gains are maintained . Regarding early intervention strategies, it is generally recommended that an early intervention service should be provided longer than 2 years  or, alternatively, new strategies should be developed to produce more sustainable effects of short-term intensive early intervention programs. For children and adolescents with EOP, studies on the effectiveness of such programs or special needs within these programs are necessary. While initial evidence suggests that early intervention works in adolescents , the duration of untreated psychosis was found to be clearly longer in adolescents than in adults despite early detection efforts [11, 12]. However, the reasons for this are not known. Potential reasons are: insufficient knowledge about psychotic symptoms in the respective health care service (including child and adolescent psychiatry/psychology); a more insidious onset of symptoms; more negative symptoms; higher rates of refusal to seek help, and overlooking symptoms or misinterpreting them as adolescent crisis by parents and teachers.
Predictive validity of current at-risk criteria in children and adolescents: To date, only two rather small studies assessed conversion rates exclusively in children and adolescents. Cornblatt  (48, 12- to 18-year-old, adolescents with attenuated psychotic symptoms) reported that at-risk adolescents converted to psychosis later than expected from studies of adults. However, Ziermans  (58, 12- to 18-year-old, adolescents with UHR criteria or COGDIS) reported that the conversion rate was slightly lower but not delayed compared to adults (16 % in 2 years). Data on children below age 12 are not available.
Assessment issues: Apart from the schizophrenia proneness instrument–child and youth version (SPI–CY; ) for the assessment of basic symptoms in children and adolescents (age 8–17), no age-adapted tools for the assessment of the other at-risk criteria in children and adolescents exist. As most studies on adults included some adolescents (≥age 15), it is probably safe to use current assessment tools in this age group (e.g., SIPS  or CAARMS ); whereas, it is not known whether at-risk criteria are valid in this age group. However, it is unclear (1) at what age children are able to provide reliable account of at-risk symptoms, (2) when and how parental reports should be considered, and (3) how a differential diagnosis to relevant child and adolescent psychiatric disorders should be made (e.g., autism spectrum disorders).
Significance of at-risk symptoms in the general population of children and adolescents: To date, it is not fully understood whether at-risk symptoms are so common among children and adolescents that a valid distinction between ill and non-ill youngsters is difficult . This question came into focus with several studies in adults and children that report high rates of standardized lay person or self-report assessed psychotic-like experiences in the general population . However, only three studies addressed this question to date in adults  and adolescents [3, 23] using appropriate clinical assessments of at-risk criteria. All the three studies found rather low rates of APS or BLIPS in children (age 11–13; 0.9–8.1 % depending on UHR definition ) or adults (age 16–40; 0–2 % ) as well as COPER (<3 %) and COGDIS (<8.0 %) in adolescents . Notably, in children and adolescents, 63 % of adolescents with APS or BLIPS met criteria for at least one past or present axis-I diagnosis according to DSM-IV . They also had poorer psychosocial functioning than the control group. In the pilot-study on adults, similar findings were reported . These rather preliminary findings support the notion that current at-risk criteria, if carefully assessed, are less prevalent than expected from studies on psychotic-like experiences and related to some impairment. Furthermore, the clinical relevance of (atypical) psychotic symptoms in children and their predictive validity for a psychotic disorder is still not fully understood. While several studies confirm the transient and atypical nature of (atypical) psychotic symptoms in children with low conversion rates to psychotic disorders [24, 25, 26], the Dunedin birth cohort study reported that psychotic symptoms at age 11 predicted the emergence of a schizophreniform disorder at age 26, but also of an anxiety disorder .
Regarding clinical implications, child and adolescent psychiatry is far from having a sufficient evidence base for creating appropriate strategies for the early detection and early intervention in psychosis in this age group. However, regarding early intervention, initial evidence suggests that adolescents (age 14–17) benefit from early intervention programs to a degree that is comparable to the benefit of young adults [6, 7]. Yet, age-appropriate early detection strategies may be necessary to reduce the duration of untreated psychosis in adolescents. The early detection of psychosis in the prodromal stage is difficult in both adults and children/adolescents. However, the proposal of an Attenuated Psychosis Syndrome for inclusion in DSM-5 reflects the fact that patients with APS indeed experience distress and significant impairment, so that treatment seems justified independent of conversion risk to psychosis. While the evidence is sparse, our experience is that this may also be true in children and adolescents. They (and their parents or carers) suffer from at-risk symptoms, appreciate their competent assessment and are interested in focusing on them in the treatment process, independent of conversion risk. The concern that an increased use of antipsychotics in children and adolescents might follow the introduction of a non-validated Attenuated Psychosis Syndrome, voiced by Arango , may be true. However, the availability of a child and adolescent psychiatrist with special training and sufficient experience in the assessment of at-risk symptoms in this age group will be most welcomed in the mental health system. This would prevent an unjustified and potentially stigmatizing, yet commonly encountered pseudo-diagnosis of “pre-psychotic” or “prodromal” for these patients, and may thereby limit premature or prolonged use of antipsychotics. To this, it is recommended that adult and child and adolescent psychiatrists work together in a team and that the clinical significance and predictive validity of current at-risk criteria in children and adolescents is further studied.
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