European Child & Adolescent Psychiatry

, Volume 21, Issue 4, pp 237–238 | Cite as

Would some cannabinoids ameliorate symptoms of autism?

Letter to the Editor


  1. 1.
    Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M (2011) Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci 12:524–538PubMedCrossRefGoogle Scholar
  2. 2.
    Green JJ, Hollander E (2010) Autism and oxytocin: new developments in translational approaches to therapeutics. Neurotherapeutics 7:250–257PubMedCrossRefGoogle Scholar
  3. 3.
    Andari E, Duhamel JR, Zalla T, Herbrecht E, Leboyer M, Sirigu A (2010) Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci USA 107:4389–4394PubMedCrossRefGoogle Scholar
  4. 4.
    Sala M, Braida D, Lentini D et al (2011) Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism. Biol Psychiatry 69:875–882PubMedCrossRefGoogle Scholar
  5. 5.
    Wainwright A, Rutter AR, Seabrook GR, Reilly K, Olivier KR (2004) Discrete expression of TRPV2 within the hypothalamo-neurohypophysial system: implications for regulatory activity within the hypothalamic–pituitary–adrenal axis. J Comp Neurol 474:24–42PubMedCrossRefGoogle Scholar
  6. 6.
    Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Peterson-Zeitz KR (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306–313PubMedCrossRefGoogle Scholar
  7. 7.
    Qin N, Neeper MP, Liu Y, Hutchinson TL, Lubin ML, Flores CM (2008) TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci 28:6231–6238PubMedCrossRefGoogle Scholar
  8. 8.
    Scuderi C, Filippis DD, Iuvone T, Blasio A, Steardo A, Esposito G (2009) Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. Phytother Res 23:597–602PubMedCrossRefGoogle Scholar
  9. 9.
    Onaivi ES, Benno R, Halpern T et al (2011) Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders. Curr Neuropharmacol 9:209–214PubMedCrossRefGoogle Scholar
  10. 10.
    Belzung C, Leman S, Vourc’h P, Andres C (2005) Rodents model for autism: a critical review. Drug Discov Today Dis Models 2:93–101CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Psychiatric Hospital of the CrossJalledibLebanon
  2. 2.Saint Joseph UniversityBeirutLebanon

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