European Child & Adolescent Psychiatry

, Volume 18, Issue 7, pp 458–463 | Cite as

ECT for self-injury in an autistic boy

  • Lee E. Wachtel
  • Stephanie A. Contrucci-Kuhn
  • Merrie Griffin
  • Ainsley Thompson
  • Dirk M. Dhossche
  • Irving M. Reti
CASE REPORT

Abstract

Objective

Self-injurious behavior presents a significant challenge in autism, and first-line psychopharmacological and behavioral interventions have limited efficacy in some patients. These intractable cases may be responsive to electroconvulsive therapy.

Clinical picture

This article presents an eight-year-old boy with autism, mental retardation, prominent mood lability and a five-year history of extreme self-injurious behavior towards his head, averaging 109 self-injurious attempts hourly. The patient was at high risk for serious head trauma, and required usage of bilateral arm restraints and protective equipment (i.e., padding on shoulders, arms, and legs). All areas of daily functioning were profoundly impacted by dangerous self-injury.

Treatment

Fifteen bilateral ECT treatments resulted in excellent mood stabilization and reduction of self-injury to 19 attempts hourly, and maintenance ECT was pursued. The patient was able to return to developmentally-appropriate educational and social activities.

Conclusion

ECT should be considered in the treatment algorithm of refractory cases of severe self-injury in autism.

Keywords

self-injury autism ECT mental retardation catatonia 

References

  1. 1.
    Aman MG, Collier-Crespin A, Lindsay RL (2000) Pharmacotherapy of disorders in mental retardation. Eur Child Adolesc Psychiatry 9:I98–I107PubMedCrossRefGoogle Scholar
  2. 2.
    American Association on Mental Retardation (2000) Treatment of psychiatric and behavioral problems in mental retardation. Am J Ment Retard 105:165–188CrossRefGoogle Scholar
  3. 3.
    American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, DCGoogle Scholar
  4. 4.
    Arora M, Praharaj SK, Prakash R (2008) Electroconvulsive therapy for multiple major self-mutilations in bipolar psychotic depression. Turk J Psychiatry 19(2):1–4Google Scholar
  5. 5.
    Aziz M, Maixner D, DeQardo J, Aldridge A, Tandon R (2001) ECT and mental retardation: a review and case report. J ECT 17:149–152PubMedCrossRefGoogle Scholar
  6. 6.
    Bates W, Smeltzer D (1982) Electroconvulsive treatment of psychotic self-injurious behavior in a patient with severe mental retardation. Am J Psychiatry 139:1355–1356PubMedGoogle Scholar
  7. 7.
    Bender L (1947) One hundred cases of childhood schizophrenia treated with electric shock. Trans Am Neurol Soc 72:165–169Google Scholar
  8. 8.
    Billstedt E, Gilberg C, Gilberg C (2005) Autism after adolescence: population-based 13- to 22-year follow-up study of 120 individuals with autism diagnosed in childhood. J Autism Dev Disord 35:351–360PubMedCrossRefGoogle Scholar
  9. 9.
    Black D, Wilcox J, Stewart M (1985) The use of ECT in children: case-report. J Clin Psychiatry 46:98–99PubMedGoogle Scholar
  10. 10.
    Borthwick-Duffy SA (1994) Epidemiology and prevalence of psychopathology in people with mental retardation. J Consult Clin Psychol 62(1):17–27PubMedCrossRefGoogle Scholar
  11. 11.
    Buitelaar JK, Willemsen-Swinkels SHN (2000) Medication treatment in subjects with autism spectrum disorders. Eur Child Adolesc Psychiatry 9:I85–I97PubMedCrossRefGoogle Scholar
  12. 12.
    Bush G, Fink M, Petrides G, Dowling F, Francis A (1996) Catatonia. I: rating scale and standardized examination. Acta Psychiatr Scand 93:129–136PubMedCrossRefGoogle Scholar
  13. 13.
    Carr V, Dorrington C, Schrader G, Wale J (1983) The use of ECT for mania in childhood bipolar disorder. Br J Psychiatry 143:411–415PubMedCrossRefGoogle Scholar
  14. 14.
    Chung A, Varghese J (2008) Treatment of catatonia with electroconvulsive therapy in an 11-year-old girl. Aust NZ J Psychiatry 42:251–253CrossRefGoogle Scholar
  15. 15.
    Cizadlo B, Wheaton A (1995) Case study: ECT treatment of a young girl with catatonia. J Am Acad Child Adolesc Psychiatry 34:332–335PubMedCrossRefGoogle Scholar
  16. 16.
    Dhossche D, Shah A, Wing L (2006) Blueprints for the assessment, treatment, and future study of catatonia in autism spectrum disorders. Int Rev Neurobiol 72:267–284PubMedCrossRefGoogle Scholar
  17. 17.
    Esmaili T, Malek A (2007) Electroconvulsive therapy (ECT) in a six-year-old girl suffering from major depressive disorder with catatonic features. Eur Child Adolesc Psychiatry 16:58–60PubMedCrossRefGoogle Scholar
  18. 18.
    Fink M (1999) Electroshock: healing mental illness. Oxford University Press, LondonGoogle Scholar
  19. 19.
    Fink M, Taylor M (2003) Catatonia: a clinician’s guide to diagnosis and treatment. University Press, CambridgeGoogle Scholar
  20. 20.
    Fink M, Taylor M, Ghaziuddin N (2006) Catatonia in autistic spectrum disorders: a medical treatment algorithm. Int Rev Neurobiol 72:233–244PubMedCrossRefGoogle Scholar
  21. 21.
    Ghaziuddin M, Quinlan P, Ghaziuddin N (2005) Catatonia in autism: a distinct subtype? J Intell Disabil Res 49:102–105CrossRefGoogle Scholar
  22. 22.
    Heuyer G, Bour, Leroy R (1943) L’electrochoc chez les enfants. Ann Med Psychol (Paris) 2:402–407Google Scholar
  23. 23.
    Johnson WL, Baumeister AA (1978) Self-injurious behavior: a review and analysis of methodological details of published studies. Behav Modif 2:465–487CrossRefGoogle Scholar
  24. 24.
    Kahng SWIB, Lewin AB (2002) Behavioral treatment of self-injury, 1964–2000. Am J Ment Retard 107(3):212–221PubMedCrossRefGoogle Scholar
  25. 25.
    Kakooza-Mwesige A, Wachtel L, Dhossche D (2008) Catatonia in autism: implications across the life span. Eur Child Adolesc Psychiatry 17(6):327–335PubMedCrossRefGoogle Scholar
  26. 26.
    Kemp ASFP, Lenjavi MR, Lyon M, Chicz-DeMet A, Touchette PE, Sandman CA (2007) Temporal patterns of self-injurious behavior correlate with stress hormone levels in the developmentally disabled. Psychiatry Res 157:181–189PubMedCrossRefGoogle Scholar
  27. 27.
    King BH, Cromwell HC, Lee HT, Behrstock SP, Schmanke T, Maidment NT (1998) Dopaminergic and glutamatergic interactions in the expression of self-injurious behavior. Dev Neurosci 20:180–187PubMedCrossRefGoogle Scholar
  28. 28.
    Leonhard K (1979) The classification of endogenous psychoses. In: Robins E (ed). Irvington, New YorkGoogle Scholar
  29. 29.
    Matson JLBJ, Mayville EA, Pinkston J, Bielecki J, Kuhn DE, Smalls Y, Logan JR (2000) Psychopharmacology and mental retardation: a 10 year review. Res Dev Disabil 21:263–296PubMedCrossRefGoogle Scholar
  30. 30.
    McDougle CJSL, Aman MG, McCracken JT, Tierney E, Davies M, Arnold LE, Posey DJ, Martin A, Ghuman JK, Shah B, Chuang SZ, Swiezy NB, Gonzalez NM, Hollway J, Koenig K, McGough JJ, Ritz L, Vitiello B (2005) Risperidone for the core symptoms of autism: results from the study by the autism network of the research units on pediatric psychopharmacology. Am J Psychiatry 162(6):1142–1148PubMedCrossRefGoogle Scholar
  31. 31.
    Paclawskyj TR, Kurtz PF, O’Connor JT (2004) Functional assessment of problem behaviors in adults with mental retardation. Behav Modif 28(5):649–667PubMedCrossRefGoogle Scholar
  32. 32.
    Reinblatt S, Rifkin A, Freeman J (2004) The efficacy of ECT in adults with mental retardation experiencing psychiatric disorders. J ECT 20:208–212PubMedCrossRefGoogle Scholar
  33. 33.
    Russell P, Tharyan P, Arun Kumar K, Cherian A (2002) Electroconvulsive therapy in a pre-pubertal child with severe depression. J Postgrad Med 48:290–291PubMedGoogle Scholar
  34. 34.
    Sanacora G, Mason G, Rothman D, Hyder F, Ciarcia J, Ostroff R, Berman R, Krystal J (2003) Increased cortical GABA concentrations in depressed patients receiving ECT. Am J Psychiatry 160:577–579PubMedCrossRefGoogle Scholar
  35. 35.
    Sandman C, Touchette P, Lenjavi M, Marion S, Chicz-DeMet A (2003) B-endorphin and ACTH are dissociated after self-injury in adults with developmental disabilities. Am J Ment Retard 108:414–424PubMedCrossRefGoogle Scholar
  36. 36.
    Schroeder S, Oster-Granite M, Berkson G, Bodfish J, Breese G, Cataldo M, Cook E, Crnic L, DeLeon I, Fisher W, Harris J, Horner R, Iwata B, Jinnah H, King B, Lauder J, Lewis M, Newell K, Nyhan W, Rojahn J, Sackett G, Sandman C, Symons F, Tessel R, Thompson T, Wong D (2001) Self-injurious behavior: gene-brain-behavior relationships. Ment Retard Dev Disabil Res Rev 17:3–12CrossRefGoogle Scholar
  37. 37.
    Stauder K (1934) Die todliche Katatonie. Arch Psychiatr Nervenkrank 102:614–634CrossRefGoogle Scholar
  38. 38.
    Tate BG, Baroff GS (1966) Aversive control of self-injurious behavior in a psychotic boy. Behav Res Ther 4(4):281–287PubMedCrossRefGoogle Scholar
  39. 39.
    Thuppal M, Fink M (1999) Electroconvulsive therapy and mental retardation. J ECT 15:140–149PubMedGoogle Scholar
  40. 40.
    Tiefenbacher S, Novak M, Marinus L, Chase W, Miller J, Meyer J (2004) Altered hypothalamic-pituitary-adrenocortical function in rhesus monkeys (Macaca mulatta) with self-injurious behavior. Psychoneuroendocrinology 29:501–515PubMedCrossRefGoogle Scholar
  41. 41.
    Wachtel LE, Hagopian LP (2006) Psychopharmacology and applied behavioral analysis: tandem treatment of severe problem behaviors in intellectual disability and a case series. Isr J Psychiatry Relat Sci 43(4):265–274PubMedGoogle Scholar
  42. 42.
    Wachtel L, Kahng S, Dhossche D, Cascella N, Reti I (2008) Electroconvulsive therapy for catatonia in an autistic girl. Am J Psychiatry 165:329–333PubMedCrossRefGoogle Scholar
  43. 43.
    Walter G, Rey J (1997) An epidemiological study of the use of ECT in adolescents. J Am Acad Child Adolesc Psychiatry 36:809–815PubMedCrossRefGoogle Scholar
  44. 44.
    Walter G, Koster K, Rey J (1999) Electroconvulsive therapy in adolescents: experience, knowledge, and attitudes of recipients. J Am Acad Child Adolesc Psychiatry 38:594–599PubMedGoogle Scholar
  45. 45.
    Willoughby C, Hradek E, Richards N (1997) Use of electroconvulsive therapy with children: an overview and case report. J Child Adolesc Psychiatr Nurs 10:11–17PubMedCrossRefGoogle Scholar
  46. 46.
    Wing L, Shah A (2000) Catatonia in autistic spectrum disorders. Br J Psychiatry 176:357–362PubMedCrossRefGoogle Scholar
  47. 47.
    Yoshida K, Higuchi H, Kamata M, Yoshimoto M, Shimizu T, Hishikawa Y (1998) Single and repeated electroconvulsive shocks activate dopaminergic and 5-hydroxytryptaminergic neurotransmission in the frontal cortex of rats. Prog Neuropsychopharmacol Biol Psychiatry 22:435–444PubMedCrossRefGoogle Scholar
  48. 48.
    Yuuki N, Ida I, Oshima A, Kumano H, Takahashi K, Fukuda M, Oriuchi N, Endo K, Matsuda H, Mikuni M (2005) HPA axis normalization, estimated by DEX/CRH test, but less alteration on cerebral glucose metabolism in depressed patients receiving ECT after medication treatment failures. Acta Psychiatr Scand 112:257–265PubMedCrossRefGoogle Scholar
  49. 49.
    Zaw F, Bates G, Murali V, Bentham P (1999) Catatonia, autism, and ECT. Dev Med Child Neurol 41:843–845PubMedCrossRefGoogle Scholar

Copyright information

© Steinkopff Verlag Darmstadt 2009

Authors and Affiliations

  • Lee E. Wachtel
    • 1
  • Stephanie A. Contrucci-Kuhn
    • 1
  • Merrie Griffin
    • 2
  • Ainsley Thompson
    • 1
  • Dirk M. Dhossche
    • 3
  • Irving M. Reti
    • 4
  1. 1.Kennedy Krieger InstituteJohns Hopkins School of MedicineBaltimoreUSA
  2. 2.Department of AnesthesiologyJohns Hopkins School of MedicineBaltimoreUSA
  3. 3.Department of PsychiatryUniversity of Mississippi Medical CenterJacksonUSA
  4. 4.Department of PsychiatryJohns Hopkins School of MedicineBaltimoreUSA

Personalised recommendations