Externalizing behaviors in preadolescents: familial risk to externalizing behaviors, prenatal and perinatal risks, and their interactions
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Accumulating evidence indicates that there is a rich and varied interplay between persons and their environments, which strongly suggests that this involves gene-environment correlations and interactions. We investigated whether familial risk (FR) to externalizing behaviors and prenatal and perinatal risk factors, separately or in interaction with each other, predicted externalizing behaviors.
The subjects were 10- to 12-year-old preadolescents who were taking part in TRAILS, a large prospective population-based cohort study (N = 2,230). Regression analyses were used to determine the relative contribution of FR and prenatal and perinatal risks to parent and teacher ratings of inattention, hyperactivity/impulsivity aggression, and delinquency.
Regression models explained between 6 and 11% of the variance of externalizing behaviors. We found main effects of FR (vs. no FR), macrosomia (birth weight > 4,500 g), maternal prenatal smoking (MPS), pregnancy and delivery complications (PDCs), and gender that were rather consistent across rater and outcome measures. For some outcome measures, the effect of MPS and PDCs depended on the presence of FR. These included both positive and negative interaction effects. Correlations between FR and prenatal and perinatal risks were significant but rather low.
Both main effects and interaction effects of FR and prenatal and perinatal risks contributed to externalizing behaviors in preadolescents, but all effects were of small size. Further research including use of candidate gene polymorphisms is necessary to identify the underlying neurobiological mechanisms of these main and interaction effects.
Keywordsexternalizing behavior familial risk prenatal and perinatal risks gene-environment interaction
- 1.Achenbach TM (1991) Manual for the child behavior checklist/4–18 and 1991 profile. University of Vermont, BurlingtonGoogle Scholar
- 3.American College of Obstetricians and Gynecologists (1991) Fetal macrosomia. Technical Bulletin 159. ACOG, WashingtonGoogle Scholar
- 4.American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorder, 4th edn. American Psychiatric Association, WashingtonGoogle Scholar
- 13.Buschgens CJM, Van Aken MAG, Swinkels SHN, Ormel J, Verhulst F, Buitelaar JK (submitted) Externalizing behaviors in preadolescents: familial risk and perceived parenting stylesGoogle Scholar
- 18.Gillberg C (1995) Clinical child neuropsychiatry. Cambridge University Press, CambridgeGoogle Scholar
- 24.Knopik VS, Sparrow EP, Madden PA, Bucholz KK, Hudziak JJ, Reich W, Slutske WS, Grant JD, McLaughlin TL, Todorov A, Todd RD, Heath AC (2005) Contributions of parental alcoholism, prenatal substance exposure, and genetic transmission to child ADHD risk: a female twin study. Psychol Med 35:625–635PubMedCrossRefGoogle Scholar
- 30.Nadder TS, Rutter M, Silberg JL, Maes HH, Eaves LJ (2002) Genetic effects on the variation and covariation of attention deficit-hyperactivity disorder (ADHD) and oppositional-defiant disorder/conduct disorder (Odd/CD) symptomatologies across informant and occasion of measurement. Psychol Med 32:39–53PubMedCrossRefGoogle Scholar
- 35.Ormel J, Oldehinkel AJ, Ferinand RF, Hartman CA, De Winter AF, Veenstra R, Vollebergh W, Minderaa R, Buitelaar JK, Verhulst FC (2005) Internalizing and externalizing problems in adolescence: general and dimension-specific effects of familial loadings and preadolescent temperament traits. Psychol Med 35:1825–1835PubMedCrossRefGoogle Scholar
- 36.Parsons TJ, Power C, Logan S, Summerbell CD (1999) Childhood predictors of adult obesity: a systematic review. Int J Obes Relat Metab Disord 8:s1–s107Google Scholar
- 47.Thapar A, Langley K, Fowler T, Rice F, Turic D, Whittinger N, Aggleton J, Van Den Bree M, Owen M, O’Donovan M (2005) Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 62:1275–1278PubMedCrossRefGoogle Scholar