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European Child & Adolescent Psychiatry

, Volume 12, Issue 4, pp 198–202 | Cite as

No evidence for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes

  • C. Marino
  • R. Giorda
  • L. Vanzin
  • M. Molteni
  • M. L. Lorusso
  • M. Nobile
  • C. Baschirotto
  • M. Alda
  • M. Battaglia
ORIGINAL CONTRIBUTION

Abstract.

Dopamine genes are candidate genes for dyslexia in the light of the well-known comorbidity between dyslexia and ADHD. Within-family association and linkage disequilibrium were tested between four genetic markers at DRD4, DRD3, DRD2, and DAT loci, and dyslexia, in a sample of 130 Italian dyslexic children, 16.9% of whom had comorbid ADHD.No evidence of either association or linkage disequilibrium was found, neither in the total sample nor in the comorbid subgroup. Negative results do not support a common genetic basis between these two disorders for these markers.

Key words

dyslexia genetics TDT dopamine receptors 

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Copyright information

© Steinkopff Verlag 2003

Authors and Affiliations

  • C. Marino
    • 1
  • R. Giorda
    • 2
  • L. Vanzin
    • 1
  • M. Molteni
    • 1
  • M. L. Lorusso
    • 1
  • M. Nobile
    • 1
  • C. Baschirotto
    • 2
  • M. Alda
    • 3
  • M. Battaglia
    • 1
    • 4
    • 5
  1. 1.Scientific Institute "Eugenio Medea"Department of Child PsychiatryBosisio Parini (LC)Italy
  2. 2.Molecular Biology LaboratoryBosisio Parini (LC)Italy
  3. 3.Dalhousie University, Department of Psychiatry, HalifaxHalifaxCanada
  4. 4.Department of PsychologySan Raffaele Vita-Salute UniversityMilanItaly
  5. 5.Scientific Institute San Raffaele Milan, Department of Neuropsychiatric SciencesMilanItaly

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