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Does the administration of meloxicam before head and neck radiotherapy reduce the risk of mandibular osteoradionecrosis? An animal model study

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Abstract

Objective

To assess whether the administration of meloxicam before head and neck radiotherapy reduces the risk of mandibular osteoradionecrosis in rats.

Material and methods

Sixty male Wistar rats were randomly divided into 6 groups (n = 10) according to the meloxicam administration and radiation therapy: control (C), irradiated (I), single dose of meloxicam (M1), single dose of meloxicam and irradiated (M1I), triple dose of meloxicam (M3), triple dose of meloxicam and irradiated (M3I). Meloxicam was administrated (20 mg/kg per dose) 1 h before the radiation therapy (single dose of 20 Gy) and 24 h and 48 h after the radiation therapy for groups with two additional doses. Ten days after the radiation therapy, the three right mandibular molars were extracted from all rats, who were euthanatized after 21 or 35 days (n = 5 per group). The mandibles were assessed by macroscopic evaluation and micro-CT analysis.

Results

The right hemimandibles of the irradiated groups revealed macroscopic signs of osteoradionecrosis, and those of the non-irradiated groups revealed complete gingival healing. A significant delay in alveolar socket healing in all irradiated groups was observed in the micro-CT assessment regardless meloxicam treatment.

Conclusion

The administration of meloxicam before head and neck radiotherapy does not reduce the risk of mandibular osteoradionecrosis when associated to dental extractions.

Clinical relevance

Since meloxicam has been shown to be a potential radiation-protective agent, and osteoradionecrosis physiopathology is believed to be related to an inflammatory process, possible interactions are relevant to be investigated.

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Acknowledgments

The authors would like to thank the Oncology Center of the Hospital Fornecedores de Cana for the assistance during the experimental phase of the study.

Funding

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.

Author information

Authors and Affiliations

  1. Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, University of Campinas, Av. Limeira, 901, PO Box 52, Piracicaba, SP, 13414-903, Brazil

    Mayra Cristina Yamasaki, Gina Delia Roque-Torres, Leonardo Vieira Peroni, Eduarda Helena Leandro Nascimento, Matheus Lima Oliveira & Deborah Queiroz Freitas

  2. Université de Paris, Orofacial Pathologies, Imaging and Biotherapies UR2496 Lab, F-92120, Montrouge, France

    Benjamin Salmon

  3. Dental Medicine Department, AP-HP, Bretonneau hospital, F-75018, Paris, France

    Benjamin Salmon

  4. Department of Restorative Dentistry, Division of Dental Materials, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil

    Lourenço Correr-Sobrinho

Authors
  1. Mayra Cristina Yamasaki
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  2. Gina Delia Roque-Torres
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  3. Leonardo Vieira Peroni
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  4. Eduarda Helena Leandro Nascimento
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  5. Benjamin Salmon
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  6. Matheus Lima Oliveira
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  7. Deborah Queiroz Freitas
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  8. Lourenço Correr-Sobrinho
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Corresponding author

Correspondence to Mayra Cristina Yamasaki.

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Conflict of interest

The author Mayra Cristina Yamasaki has received research grants from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) during the conduct of the study.

Ethical approval

All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted (Comissão de Ética no Uso de Animais da Universidade Estadual de Campinas—CEUA/UNICAMP—Protocol #3817-1).

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For this study, informal consent was not required.

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Yamasaki, M.C., Roque-Torres, G.D., Peroni, L.V. et al. Does the administration of meloxicam before head and neck radiotherapy reduce the risk of mandibular osteoradionecrosis? An animal model study. Clin Oral Invest 25, 3739–3745 (2021). https://doi.org/10.1007/s00784-020-03701-x

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  • DOI: https://doi.org/10.1007/s00784-020-03701-x

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