Efficiency of desensitizing materials in xerostomic patients with head and neck cancer: a comparative clinical study
- 31 Downloads
To assess the clinical effectiveness of four desensitizing materials in patients who are xerostomic due to radiotherapy for head and neck cancer (HNC) in comparison to a healthy group with normal salivation.
Methods and materials
The study was conducted as a split-mouth randomized clinical trial. Forty HNC patients (group A) and 46 healthy patients (group B) suffering from dentin hypersensitivity (DH) were included. Salivary flow was determined through a scialometric test. Hypersensitivity was assessed with air stimulus and tactile stimulus. The materials used as desensitizing agents were Vertise Flow, Universal Dentin Sealant, Clearfil Protect Bond, and Flor-Opal Varnish. The response was recorded before application of the materials, immediately after, and at 1 week, 4 weeks, and 12 weeks.
Salivary flow rates in groups A/B were 0.15/0.53 mL/min (unstimulated) and 0.54/1.27 mL/min (stimulated), respectively. In group A, 100 hypersensitive teeth were included. Application of the desensitizing agents significantly decreased the hypersensitivity immediately and throughout the 4-week follow-up (p < 0.001). However, after the 12-week timepoint, a loss of efficacy was detected in all agents (p = 0.131). In group B, 116 hypersensitive teeth were included. The materials performed a more stable action, although a loss of effectiveness was detected at 12-week control (p = 0.297).
The efficiency of the desensitizing agents after the first application was similar in both groups. In the radiated group, this effect lasted for shorter periods than in healthy controls.
HNC patients with hyposalivation may be a new risk group for DH.
KeywordsDry mouth Hyposalivation Dentin hypersensitivity Radiation therapy Head and neck cancer
The authors declare that no financial relationships exist regarding any of the products involved in this study.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
The protocol and informed consent forms were approved by the Ethics Committee of the University of Sassari (no. 1000/CE).
The study followed CONSORT guidelines and was registered at the US National Institutes of Health (ClinicalTrials.gov) # NCT02766127.
Informed consent was obtained from all individual participants included in the study.
- 4.Hahnel S, Schwarz S, Zeman F, Schäfer L, Behr M (2014) Prevalence of xerostomia and hyposalivation and their association with quality of life in elderly patients in dependence on dental status and prosthetic rehabilitation: a pilot study. J Dent 42:664–670. https://doi.org/10.1016/j.jdent.2014.03.003 CrossRefPubMedGoogle Scholar
- 12.Delaviz Y, Finer Y, Santerre JP (2014) Biodegradation of resin composites and adhesives by oral bacteria and saliva: a rationale for new material designs that consider the clinical environment and treatment challenges. Dent Mater 30:16–32. https://doi.org/10.1016/j.dental.2013.08.201 CrossRefPubMedGoogle Scholar
- 13.Milia E, Pinna R, Filigheddu E, Eramo S (2016) Adhesive restorations and the oral environmental behaviour. In: Rudawska A (ed) Adhesives–applications and properties. Rijeka, InTech, pp 137–165Google Scholar
- 15.Jones SB, Parkinson CR, Jeffery P, Davies M, Macdonald EL, Seong J et al (2015) A randomised clinical trial investigating calcium sodium phosphosilicate as a dentine mineralising agent in the oral environment. J Dent 43:757–764. https://doi.org/10.1016/j.jdent.2014.10.005 CrossRefPubMedGoogle Scholar
- 25.Sreebny LM (1996) Xerostomia: diagnosis, management and clinical complications. In: Edgar WM, O’Mullane DM (eds) Saliva and oral health, 2nd edn. British Dental Association, London, pp 43–66Google Scholar
- 28.Wang L, Magalhães AC, Francisconi-Dos-Rios LF, Calabria MP, Araújo D, Buzalaf M, Lauris J, Pereira JC (2016) Treatment of dentin hypersensitivity using Nano-hydroxyapatite pastes: a randomized three-month clinical trial. Oper Dent 41:E93–E101. https://doi.org/10.2341/15-145-C CrossRefPubMedGoogle Scholar
- 42.Vogl V, Hiller KA, Buchalla W, Federlin M, Schmalz G (2016) Controlled, prospective, randomized, clinical split-mouth evaluation of partial ceramic crowns luted with a new, universal adhesive system/resin cement: results after 18 months. Clin Oral Investig 20(9):2481–2492. https://doi.org/10.1007/s00784-016-1779-2 CrossRefPubMedGoogle Scholar