Direct oral anticoagulants, vitamin K antagonists, and simple single tooth extraction
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Dear Editor, we read the publication on “Should we fear direct oral anticoagulants more than vitamin K antagonists in simple single tooth extraction? A prospective comparative study” with great interest . Berton et al. concluded that “Patients assuming DOACs can be treated similarly to patients in VKAs therapy with INR index between 2 and 3 .” In fact, the management of the patients receiving any medication affecting hemostasis is an important consideration in dental surgery. The good decision-making should base on the coagulation test results. Nevertheless, there is still an important precaution on the interpretation of INR index. In laboratory medicine, different laboratory reagents can result in different INR index values. As reported by Morrison et al., the INR value by Manchester method is lower than those values obtained by the other methods . Also, the sensitivity of a thromboplastin reagent to heparin can result in false increased INR value . To interpret INR index, the dentist has to recognize about the problem of false value. At least, the dentist should recheck by history, taking to rule out any risk of bleeding tendency of the patients.
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The authors declare no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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- 1.Berton F, Costantinides F, Rizzo R, Franco A, Contarin J, Stacchi C, Maglione M, Visintini E, Di Lenarda A, Di Lenarda R (2018) Should we fear direct oral anticoagulants more than vitamin K antagonists in simple single tooth extraction? A prospective comparative study. Clin Oral Investig. https://doi.org/10.1007/s00784-018-2739-9