Association of somatosensory dysfunction with symptom duration in burning mouth syndrome
A standardized battery of quantitative sensory tests developed by the German Research Network on Neuropathic Pain (DFNS) was used to assess the association between somatosensory dysfunction and disease duration in patients with burning mouth syndrome (BMS).
Materials and methods
The 28 female participants with BMS were classified according to disease duration: ≤ 6 months (subchronic BMS, n = 15) and > 6 months (chronic BMS, n = 13); 29 age- and sex-matched healthy volunteers (control group) were recruited from staff of a dental hospital. The DFNS quantitative sensory testing protocol was applied at the ulnar surface of the right forearm and the tip of the tongue. Values for BMS patients and controls were compared and analyzed.
The mechanical detection threshold (MDT) was significantly higher (i.e., loss of sensation) at the tongue tip in the chronic BMS group than in the control group (p = 0.011), whereas mechanical pain sensitivity (MPS) at the forearm was significantly higher (i.e., gain of sensation) in the chronic BMS group than in the control group (Z score = − 2.13 and 1.99, respectively). Multivariate analyses revealed that BMS patients could be discriminated from controls by using pressure pain threshold at the tongue (79.3%) (in the subchronic BMS group) and by MDT and MPS at the tongue tip and MPS at the forearm (96.6 and 89.7%, respectively) (in the chronic BMS group).
In BMS patients with long disease duration, MDT showed loss of sensation.
Increased MPS suggests that a neuropathic mechanism in the peripheral and central nervous systems is involved in BMS development.
KeywordsBurning mouth syndrome Quantitative sensory testing German Research Network on Neuropathic Pain
This study was supported in part by research grants from the Sato and Uemura funds, Dental Research Center from the Nihon University School of Dentistry, and a Nihon University Multi-disciplinary Research Grant.
Compliance with ethical standards
Conflict of interest
The author declares that they have no conflict of interest.
This study was approved by the Ethical Committee of Nihon University School of Dentistry (EP16 D021).
Informed consent was obtained from all individual participants included in the study.
- 7.Femiano F, Gombos F, Scully C (2004) Burning mouth syndrome: the efficacy of lipoic acid on subgroups. J Eur Acad Dermatology Venereol 18(6):676–678Google Scholar
- 13.Merskey H, Bogduk N (1994) Classification of chronic pain: descriptions of chronic painsyndrome and definitions of pain terms, 2nd edn. IASP Press, SeattleGoogle Scholar
- 14.Loeser JD, Butler SH, Chapman CR, Turk DC (eds) (2001) Bonica's management of pain, 3rd edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
- 15.Berry PH, Chapman CR, Covington EC, et al (2001) Pain: current understanding of assessment, management and treatments. National Pharmaceutical Council, INCGoogle Scholar
- 16.Tighe P, Buckenmaier CC, Boezaart AP et al (2015) Acute pain medicine in the United States: a status report. Pain Med (United States) 16(9):1806–1826Google Scholar
- 17.IHS (2018) ICHD-3: the international classification of headache disorders 3rd edition. Int Headache Soc 38(1):1–211Google Scholar
- 18.Rolke R, Baron R, Maier C, Tölle TR, Treede DR, Beyer A, Binder A, Birbaumer N, Birklein F, Bötefür IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihöfner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B (2006) Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain 123(3):231–243PubMedGoogle Scholar
- 36.Wada A, Shizukuishi T, Kikuta J, Yamada H, Watanabe Y, Imamura Y, Shinozaki T, Dezawa K, Haradome H, Abe O (2017) Altered structural connectivity of pain-related brain network in burning mouth syndrome—investigation by graph analysis of probabilistic tractography. Neuroradiology 59(5):525–532PubMedGoogle Scholar