Skip to main content

Advertisement

Log in

MTA and biodentine for primary teeth pulpotomy: a systematic review and meta-analysis of clinical trials

  • Original Article
  • Published:
Clinical Oral Investigations Aims and scope Submit manuscript

Abstract

Objective

This study aims to perform a systematic review and meta-analysis of clinical trials in order to evaluate the clinical and radiographic success rates of primary teeth pulpotomy performed with biodentine, when compared to MTA.

Methods

Search strategies were conducted in nine databases on August 5th, 2017, update on February 14th, 2018. Clinical articles were selected, which were in accordance with the inclusion and exclusion criteria and the research objective. They were analyzed by meta-analysis at three time points (6, 12, and 18 months).

Results

Out of the 233 publications initially identified, only 9 studies that fulfilled the inclusion criteria were included in the review. The 6-month overall clinical (RR = 0.99; 95% CI = 0.96–1.02, p = 0.92) and radiographic success rates (RR = 0.96; 95% CI = 0.92–1.00, p = 0.28) showed that biodentine vs. MTA did not differ statistically. The 12 and 18-month overall clinical success rates, respectively (RR = 1.01; 95% CI = 0.97–1.04, p = 0.77; RR = 0.98; 95% CI = 0.92–1.05, p = 0.74) and radiographic success rates, respectively (RR = 0.97; 95% CI = 0.92–1.02, p = 0.11; RR = 1.00; 95% CI = 0.91–1.10, p = 0.56) also showed that biodentine vs. MTA did not differ statistically.

Conclusion

There is no superiority of one material over the other, MTA versus biodentine.

Clinical relevance

This systematic review comparing the performance of biodentine in relation to the MTA when used in the pulpotomy technique in primary teeth. Although MTA is considered the gold standard material for pulpotomy procedures, it has some drawbacks (poor handling, staining potential, long setting time); thus, it is important to evaluate the clinical performance of other calcium silicate-based cements like biodentine that overcome this drawbacks.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. lheozor-Ejiofor Z, Worthington HV, Walsh T et al (2015) Water fluoridation for the prevention of dental caries. Cochrane Database Syst Rev 6:CD010856. https://doi.org/10.1002/14651858.CD010856.pub2

    Article  Google Scholar 

  2. Gimenez T, Bispo BA, Souza DP, Viganó ME, Wanderley MT, Mendes FM, Bönecker M, Braga MM (2016) Does the decline in caries prevalence of Latin American and Caribbean children continue in the new century? Evidence from systematic review with meta-analysis. PLoS One 11:e0164903

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kassebaum NJ, Smith AGC, Bernabé E, Fleming TD, Reynolds AE, Vos T, Murray CJL, Marcenes W, GBD 2015 Oral Health Collaborators, Abyu GY, Alsharif U, Asayesh H, Benzian H, Dandona L, Dandona R, Kasaeian A, Khader YS, Khang YH, Kokubo Y, Kotsakis GA, Lalloo R, Misganaw A, Montero P, Nourzadeh M, Pinho C, Qorbani M, Blancas MJR, Sawhney M, Steiner C, Traebert J, Tyrovolas S, Ukwaja KN, Vollset SE, Yonemoto N (2017) Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990-2015: a systematic analysis for the global burden of diseases, injuries, and risk factors. J Dent Res 96:380–387

    Article  PubMed  PubMed Central  Google Scholar 

  4. Smaïl-Faugeron V, Courson F, Durieux P et al Pulp treatment for extensive decay in primary teeth. Cochrane Database Syst Rev 6(8):CD003220. https://doi.org/10.1002/14651858.CD003220.pub2

  5. Ng FK, Messer LB (2008) Mineral trioxide aggregate as a pulpotomy medicament: an evidence-based assessment. Eur Arch Paediatr Dent 9:58–73

    Article  PubMed  Google Scholar 

  6. American Academy of Pediatric Dentistry (2016) Guideline on pulp therapy for primary and immature permanent tooth. Clinical Guidelines – Reference Manual 2016-2017. Pediatr Dent 38:280–288

  7. Simancas-Pallares MA, Díaz-Caballero AJ, Luna-Ricardo LM (2010) Mineral troxide aggregate in primary teeth pulpotomy. A systematic literature review. Med Oral Patol Oral Cir Bucal 15:942–946

    Article  Google Scholar 

  8. Anthonappa RP, King NM, Martens LC (2013) Is there sufficient evidence to support the long-term efficacy of mineral trioxide aggregate (MTA) for endodontic therapy in primary teeth. Int Endod J 46:198–204

    Article  PubMed  Google Scholar 

  9. Lin PY, Chen HS, Wang YH, Tu YK (2014) Primary molar pulpotomy: a systematic review and network meta-analysis. J Dent 42:1060–1077

    Article  PubMed  Google Scholar 

  10. Asgary S, Shirvani A, Fazlyab M (2014) MTA and ferric sulfate in pulpotomy outcomes of primary molars: a systematic review and meta-analysis. J Clin Pediatr Dent 39:1–8

    Article  PubMed  Google Scholar 

  11. Shirvani A, Asgary S (2014) Mineral trioxide aggregate versus formocresol pulpotomy: a systematic review and meta-analysis of randomized clinical trials. Clin Oral Invest 18(4):1023–1030

    Article  Google Scholar 

  12. Stringhini Junior E, Vitcel ME, Oliveira LB (2015) Evidence of pulpotomy in primary teeth comparing MTA, calcium hydroxide, ferric sulphate, ans electrosurgery with formocresol. Eur Arch Paediatr Dent 16:303–312

    Article  PubMed  Google Scholar 

  13. Coll JA, Seale NS, Vargas K, Marghalani AA, Shamali SA, Graham L (2017) Primary tooth vial pulp therapy: a systematic review and meta-analysis. Pediatr Dent 39(1):16–27

    PubMed  Google Scholar 

  14. Marciano MA, Duarte MA, Camilleri J (2015) Dental discoloration caused by bismuth oxide in MTA in the presence of sodium hypochlorite. Clin Oral Invest 19(9):2201–2209

    Article  Google Scholar 

  15. Ramos JC, Palma PJ, Nascimento R, Caramelo F, Messias A, Vinagre A, Santos JM (2016) 1-year in vitro evaluation of tooth discoloration induced by 2 calcium silicate-based cements. J Endod 42(9):1403–1407

    Article  PubMed  Google Scholar 

  16. Marconyak LJ Jr, Kirkpatrick TC, Roberts HW, et al. (2016) A comparison of coronal tooth discoloration elicited by various endodontic reparative materials. J Endod 42:470–473

  17. Xavier SR, Pilownic KJ, Gastmann AH, Echeverria MS, Romano AR, Geraldo Pappen F (2017). Bovine tooth discoloration induced by endodontic filling materials for primary teeth. Int J Dent 2017:7401962, 1, 5

  18. Możyńska J, Metlerski M, Lipski M, Nowicka A. Tooth discoloration induced by different calcium silicate-based cements: a systematic review of in vitro studies

  19. Raju VG, Venumbaka NR, Mungara J, Vijayakumar P, Rajendran S, Elangovan A (2014) Comparative evaluation of shear bond strength and microleakage of tricalcium silicate-based restorative material and radioopaque posterior glass ionomer restorative cement in primary and permanent teeth: an in vitro study. J Ind Soc Pedod Prev Dent 32:304–310

    Article  Google Scholar 

  20. El-Khodary HM, Farsi DJ, Farsi NM, Zidan AZ (2015) Sealing ability of four calcium containing cements used for repairing furcal perforations in primary molars: an in vitro study. J Contemp Dent Pract 16:733–739

    Article  PubMed  Google Scholar 

  21. Shayegan A, Jurysta C, Atash R, Petein M, Abbeele AV (2012) Biodentine used as a pulp-capping agent in primary pig teeth. Pediatr Dent 34:e-202-208

  22. Fouad WA, Yossef R (2013) Clinical and radiographic assessment of vital pulpotomy in primary molars using mineral trioxide aggregate and a novel bioactive cement. EDJ 59:1–7

    Google Scholar 

  23. Kusum B, Rakesh K, Richa K (2015) Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth. Rest Dent Endon 40:276–285

    Article  Google Scholar 

  24. Niranjani K, Prasad MG, Vasa AAK, et al. (2015) Clinical evaluation of success of primary teeth pulpotomy using mineral trioxide aggregate®, laser and BiodentineTM – an in vivo study. J Clin Diagn Res 9:ZC35-ZC37

  25. Cuadros-Fernández C, Al LR et al (2016) Short-term treatment outcome of pulpotomies in pimary molars using mineral trioxide aggregate and biodentine: a randomized clinical trial. Clin Oral Invest 20:1639–1645

    Article  Google Scholar 

  26. Togaru H, Muppa R, Srinivas N, Naveen K, Reddy VK, Rebecca VC (2016) Clinical and radiographic evaluation of success of two commercially available pulpotomy agents in primary teeth: an in vivo study. J Contemp Dent Pract 17:557–563

    Article  Google Scholar 

  27. Bani M, Aktaş N, Çınar Ç, Odabaş ME (2017) The clinical and radiographic success of primary molar pulpotomy using biodentine and mineral trioxide aggregate: a 24-month randomized clinical trial. Pediatr Dent 39:284–288

    PubMed  Google Scholar 

  28. Carti O, Oznurhan F (2017) Evaluation and comparison of mineral trioxide aggregate and biodentine in primary tooth pulpotomy: clinical and radiographic study. Nig J Clin Pract 20:1604–1609

    Google Scholar 

  29. Juneja P, Kulkarni S (2017) Clinical and radiographic comparison of biodentine, mineral trioxide aggregate and formocresol as pulpotomy agents in primary molars. Eur Arch Paediatr Dent 18:271–278

    Article  PubMed  Google Scholar 

  30. Rajasekharan S, Martens L, Vandenbulcke J et al (2017) Efficacy of three different pulpotomy agents in primary molars – a randomized control trial. Int Endod J 50:215–228

    Article  PubMed  Google Scholar 

  31. Higgins JPT, Green S (2008) Cochrane handbook for systematic reviews of interventions version 5.0.1. The Cochrane Collaboration. Available at: www.cochrane-handbook.org

  32. Vallés M, Roig M, Duran-Sindreu F, Martínez S, Mercadé M (2015) Color stability of teeth restored with biodentine: a 6-month in vitro study. J Endod 41(7):1157–1160

    Article  PubMed  Google Scholar 

  33. Rajasekharan S, Martens LC, Cauwels RP, Anthonappa RP (2018) Biodentine TM material characteristics and clinical applications: a 3 year literature review and update. Eur Arch Paediatr Dent 19:1–22

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Luciana Butini Oliveira.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors. Informed consent: For this type of study, formal consent is not required.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Stringhini Junior, E., dos Santos, M.G.C., Oliveira, L.B. et al. MTA and biodentine for primary teeth pulpotomy: a systematic review and meta-analysis of clinical trials. Clin Oral Invest 23, 1967–1976 (2019). https://doi.org/10.1007/s00784-018-2616-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00784-018-2616-6

Keywords

Navigation