Clinical Oral Investigations

, Volume 23, Issue 4, pp 1845–1854 | Cite as

Free gingival graft adjunct with low-level laser therapy: a randomized placebo-controlled parallel group study

  • Mehmet Selim Yildiz
  • Sadiye GunpinarEmail author
Original Article



This study aimed to evaluate the effect of low-level laser therapy (LLLT) in terms of enhancing wound healing, reducing free gingival graft (FGG) shrinkage and postoperative pain.

Materials and methods

Thirty patients were randomly assigned to receive either FGG + LLLT (test, n = 15) or FGG + plasebo LLLT (control, n = 15). In the test group, a diode laser (810 nm, 0.1 W, energy density 6 J/cm2) was applied immediately after surgery and 1, 3, 7, and 14 days later. Measurements of the graft surface areas of the groups were made with an image-analyzing software at baseline and first, third, and sixth months. Complete wound epithelialization and visual analogue scale (VAS) for pain score were evaluated after surgery.


Shrinkage of the graft was statistically higher in the control than the test group at third and sixth months (p < 0.05). In terms of epithelization of the graft area, the test and control groups did not show any significant difference during the 28-day period (p > 0.05). Besides this, statistically significant differences were observed for VAS pain score and the number of analgesic used (p < 0.05).


The use of an 810-nm diode laser provided additional benefits to FGG in terms of less shrinkage of the graft dimensions and postoperative pain.

Clinical relevance

Low-level laser therapy reduced the shrinkage of free gingival graft’s surface area after 6 months and enhanced postoperative pain relief.


Free gingival graft Low-level laser therapy Shrinkage Visual analogue scale 



The authors would like to thank research assistant Mehmet Cihan Sengun (MCS) (Abant Izzet Baysal University, Faculty of Dentistry, Department of Periodontology) for his assistance in laser biostimulation.

Author contribution

Dr. Gunpinar designed the study, supervised all aspects of the research, interpreted the results, and drafted the manuscript. Dr. Yildiz performed all the surgical operations and clinical measurements.


This study was supported by Abant Izzet Baysal University Scientific Research Center in Bolu, Turkey (Project number 2016.06.05.1114).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in full accordance of the decision of the Ethics Committee of the Abant Izzet Baysal University Medical Faculty (acceptance number 2016/49) with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Periodontology, Faculty of DentistryAbant Izzet Baysal UniversityBoluTurkey

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