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Clinical Oral Investigations

, Volume 22, Issue 7, pp 2413–2430 | Cite as

Locally applied statins as adjuvants to non-surgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis

  • Jonathan Meza-Mauricio
  • David Soto-Peñaloza
  • David Peñarrocha-Oltra
  • Jose Maria Montiel-Company
  • Daiane Cristina Peruzzo
Review

Abstract

Objective

This review aimed at evaluating the effects of chronic periodontitis (CP) treatment with local statins as adjuncts to scaling and root planing (SRP), compared with SRP alone or with placebo.

Methods

Electronic and hand searches were conducted in three databases to select randomized controlled trials (RCTs) comparing SRP + statins versus SRP alone. Random effects models were conducted to determine the clinical attachment level (CAL) gain as the primary outcome variable, and probing pocket depth (PPD) reduction, modified sulcus bleeding index (mSBI), and intrabony defect depth (IBD) as the secondary outcomes.

Results

Of the 526 papers identified, 15 articles met the criteria for inclusion in this systematic review, and 13 in the meta-analysis. The meta-analysis showed a statistically significant CAL gain (mean differences [MD] = 1.84 mm, 95% confidence interval [CI] = 1.45 to 2.23; p = 0.000), PPD reduction (MD = 1.69 mm, 95% CI = 1.37 to 2.04; p = 0.000), mSBI change (MD = 0.70, 95% CI = 0.57 to 0.84; p = 0.000), and IBD (MD = 1.48, 95% CI = 1.30 to 1.67; p = 0.000) attributed to SRP + statin treatment (6 months).

Conclusion

Within the limitations of this study, the collective evidence emerging from this systematic review and meta-analysis may support the use of locally applied statins as adjuncts to SRP in CP treatment, based on being an easy, low-cost alternative, with lesser adverse effects on bacterial resistance. These results should be interpreted with caution.

Clinical relevance

Clinicians might consider the use of SRP + statins as an adjunct over other alternative approaches, based on the results of the present review. The informed decision should be taken, considering the patient’s values and preferences, and the intervention to be implemented by the clinician.

Keywords

Hydroxymethylglutaryl CoA reductases Root planing Chronic periodontitis Meta-analysis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

No ethical approval was required for this study, since no human participants or animals were used in this study.

Informed consent

Formal consent is not required for a systematic review and meta-analysis.

Supplementary material

784_2018_2507_MOESM1_ESM.docx (230 kb)
ESM 1 (DOCX 230 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jonathan Meza-Mauricio
    • 1
  • David Soto-Peñaloza
    • 2
  • David Peñarrocha-Oltra
    • 2
  • Jose Maria Montiel-Company
    • 2
  • Daiane Cristina Peruzzo
    • 3
  1. 1.Department of PeriodontologyGuarulhos UniversityGuarulhosBrazil
  2. 2.Stomatology Department School of Medicine and DentistryUniversity of ValenciaValenciaSpain
  3. 3.São Leopoldo Mandic Dental Institute and Research CentreCampinasBrazil

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