Clinical Oral Investigations

, Volume 23, Issue 1, pp 459–468 | Cite as

Pain perception following epithelialized gingival graft harvesting: a randomized clinical trial

  • Lorenzo Tavelli
  • Andrea Ravidà
  • Muhammad H. A. Saleh
  • Bartosz Maska
  • Fernando Suárez-López del AmoEmail author
  • Giulio Rasperini
  • Hom-Lay Wang
Original Article



The aim of this study was to compare the effects of a hemostatic collagen sponge and a collagen sponge sealed with a bio-adhesive material on the palatal donor sites with the purpose of minimizing postoperative pain after epithelialized gingival graft (EGG) harvesting.

Material and methods

The present study consisted of 44 EGGs harvested in 44 patients. In the control group, a hemostatic collagen sponge was applied over the palatal wound, while the test group was treated with additional cyanoacrylate. Patients were observed for 14 days, evaluating the pain level by using the visual analogic scale. The consumption of analgesic during the postoperative period, the willingness for retreatment and the characteristic of the graft were also analyzed.


Statistically significant differences in pain perception were found between test and control groups in each of the studied days (p < 0.01). Analgesic consumption was lower in the test group (p < 0.01). Graft width < 14 mm was found to be associated with lower discomfort (p < 0.01).


Adding an additional layer of cyanoacrylate over a hemostatic collagen sponge on the palatal wound following EGG harvesting was found to be successful in minimizing the postoperative discomfort and the need for analgesics.

Clinical relevance

Postoperative pain after palatal tissue harvesting can be successfully minimized if the donor site open wound is protected with an external layer of cyanoacrylate over a collagen sponge.


Pain management Autografts Free soft tissue graft Wound healing 



The authors wish to acknowledge Dr. Corrado Tavelli for his valuable support in performing the surgeries.


This paper was partially supported by the University of Michigan Periodontal Graduate Student Research Fund.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the present study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in this article.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Periodontics & Oral Medicine, School of DentistryUniversity of MichiganAnn ArborUSA
  2. 2.Department of PeriodonticsUniversity of Oklahoma Health Sciences Center - College of DentistryOklahoma CityUSA
  3. 3.Department of Biomedical, Surgical and Dental Sciences, Foundation IRCCS Ca’ Granda PolyclinicUniversity of MilanMilanItaly

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