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Clinical Oral Investigations

, Volume 23, Issue 1, pp 351–359 | Cite as

Comparison of mucosal and mucoperiosteal wound cover for the treatment of medication-related osteonecrosis of the jaw lesions: a retrospective cohort study

  • Nicola NonnenmühlenEmail author
  • A. Burnic
  • A. Bartella
  • B. Lethaus
  • F. Gerhards
  • O. Ristow
  • C. Pautke
  • F. Hölzle
  • T. Steiner
Original Article
  • 150 Downloads

Abstract

Objectives

Actually, there is no detailed guidance on how to deal with wound closure after surgical removal of medication-related osteonecrosis of the jaw (MRONJ) lesions. This study attempts to compare the difference in outcome between the mucosal and the mucoperiosteal flap closure after surgery.

Patients and methods

In this retrospective monocentric cohort study, patients (n = 61; 35 female/26 male) suffering from MRONJ and requiring surgical therapy at the University of Aachen between 2013 and 2015 were included. Due to intra-institutional variances, one group was treated with the mucosal, the other group with the mucoperiosteal technique. The success rate, i.e., mucosal closure and no relapse at the point of follow-up, was evaluated and compared. All patients were clinically investigated for the postoperative follow-up during a special consultation appointment.

Results

The success rates between the different techniques after 2 years follow-up were very similar. In the group of mucosal wound closure, 22 of 29 (75.86%) patients revealed mucosal integrity without signs of MRONJ. The rate in the mucoperiosteal wound closure group was almost identical (24 of 32 (75%)).

Conclusion

No differences in the success rates between the two different techniques could be evaluated.

Clinical relevance

The results of this study suggest that the complete removal of the necrotic bone might have a higher impact on the success rates than the technique of the wound closure. Due to the fact that the mucoperiosteal wound closure technique offers a better overview of the extent of the MRONJ lesion, the authors advise to use this technique.

Keywords

MRONJ Bisphosphonate Osteonecrosis Surgical treatment Retrospective cohort study 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study does not include any personal information of patients.

Informed consent

For this type of study formal consent is not required.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Nicola Nonnenmühlen
    • 1
    • 2
    Email author
  • A. Burnic
    • 1
  • A. Bartella
    • 1
  • B. Lethaus
    • 1
  • F. Gerhards
    • 1
  • O. Ristow
    • 3
  • C. Pautke
    • 4
    • 5
  • F. Hölzle
    • 1
  • T. Steiner
    • 1
  1. 1.Department of Oral and Maxillofacial SurgeryUniversity of AachenAachenGermany
  2. 2.Department of Oral and Maxillofacial SurgeryUniversity of AachenMönchengladbachGermany
  3. 3.Department of Oral and Maxillofacial SurgeryUniversity of HeidelbergHeidelbergGermany
  4. 4.Department of Oral and Maxillofacial SurgeryUniversity of MunichMunichGermany
  5. 5.Partner, Medicine and Aesthetics, Private Clinic for Oral and Maxillofacial and Plastic SurgeryUniversity of MunichMunichGermany

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