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Effect of platelet-rich fibrin palatal bandage on pain scores and wound healing after free gingival graft: a randomized controlled clinical trial

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Abstract

Objective

This prospective randomized clinical trial was conducted to determine whether the application of a platelet-rich fibrin (PRF) palatal bandage after harvesting free gingival grafts (FGG) would improve healing of donor sites and decrease pain scores and patient discomfort.

Materials and methods

Twenty-four patients received FGG to augment keratinized tissue dimensions. The application of a PRF bandage was decided randomly (n = 12 in each group). Patients reported their pain levels for the first 7 days of healing using the visual analog scale (VAS), 101-point numerical rating scale (NRS-101), and 4-point verbal rating scale (VRS-4). The patients’ pre-operative anxiety levels were measured using three anxiety scales. The healing of the donor sites was evaluated and compared to preoperative records. Data were assessed and recorded before surgery and at 1, 2, 3, 4, and 8 weeks postoperatively.

Results

Dental anxiety and state-trait anxiety were evaluated at baseline and correlated to the postoperative pain scores. There were no significant differences in anxiety levels between the two groups; yet, they could potentially influence the outcome of any surgery and were included as covariates. The patients in the PRF group reported significantly lower pain scores and their pain levels returned to baseline levels earlier, compared to the control group.

Conclusions

PRF palatal bandages significantly reduced postoperative pain and discomfort and facilitated wound healing after harvesting FGG.

Clinical relevance

The study provided evaluation of patient-centered outcomes, which is timely, significant, and could benefit both periodontists and patients.

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Acknowledgments

Maha A. Bahammam would like to thank the deanship of Scientific Research for technical and financial support. I also want to thank Dr. Eman Y. Elfirt at faculty of dentistry, King Abdulaziz University for conducting the post-surgical care during the follow-up visits.

Funding

This study was funesentative clinical esentative clinical esentative clinical anship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia (Grant No. 285-254-1434).

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Authors and Affiliations

  1. Department of Periodontology, Faculty of Dentistry, King Abdulaziz University, P. O. Box 80209, Jeddah, 21589, Kingdom of Saudi Arabia

    Maha A. Bahammam

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  1. Maha A. Bahammam
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Corresponding author

Correspondence to Maha A. Bahammam.

Ethics declarations

The study was approved by the King Abdulaziz University ethical committee, was carried out in accordance with the tenets of the Declaration of Helsinki [17, 18], and was registered at clinicaltrials.gov with the registration number NCT02797899.

Conflict of interest

Maha A. Bahammam declares that she has no conflict of interest.

Ethical approval

All applicable international, national, and/or institutional guidelines for the care of human beings were followed.

Informed consent

For this type of study, formal consent is not required.

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Bahammam, M.A. Effect of platelet-rich fibrin palatal bandage on pain scores and wound healing after free gingival graft: a randomized controlled clinical trial. Clin Oral Invest 22, 3179–3188 (2018). https://doi.org/10.1007/s00784-018-2397-y

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  • DOI: https://doi.org/10.1007/s00784-018-2397-y

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