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Sinus floor elevation using implants coated with recombinant human bone morphogenetic protein-2: micro-computed tomographic and histomorphometric analyses

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Abstract

Objectives

The objective of this study was to determine the validity of a graft-free sinus floor elevation (SFE) procedure with simultaneous placement of recombinant morphogenetic protein-2 (rhBMP-2)-coated implants compared to uncoated control implants.

Methods

In 10 rabbits, SFE was performed on both sides. Dental implants were randomly placed in the sinus filled with a blood clot. Test implants were coated with rhBMP-2, whereas in the control group, implants were uncoated. Micro-computed tomographic and histomophometric analyses were performed at 4 and 8 weeks, including measurement for newly formed bone height (NBHm).

Results

Bone formation was evident along the implant surfaces up to the apex in test, but limited in control implants at 4 weeks. NBHm amounted to 5.1 mm (Q1 = 4.1; Q3 = 5.3) for test implants and to 3.4 mm (2.6; 3.7) for control implants at 4 weeks. NBHm then decreased to 8 weeks (3.4 mm (3.3; 3.7)) for test implants, whereas in control sites, NBHm increased slightly to 4.4 mm (4.1; 4.5) (p = 0.1250; p = 0.6250).

Conclusions

Implants coated with rhBMP-2 presented a strong osteogenic reaction at 4 weeks with more favorable outcomes in terms of bone formation along the implant surface up to the apex compared to uncoated control implants. Remodeling and resorption process between 4 and 8 weeks did not further improve the outcomes in the test, but in the control group.

Clinical relevance

The use of rhBMP-2-coated implants in a graft-free SFE might show an advantage in early implant stability to prevent collapse of membrane. However, a potential clinical benefit still needs to be proven.

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Acknowledgements

The support of Prof. Jürg Hüsler for performing the statistical analysis is highly acknowledged.

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Author notes

  1. Daniel S. Thoma and So-Ra Yoon contributed equally to this study.

Authors and Affiliations

  1. Clinic for Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich, Zurich, Switzerland

    Daniel S. Thoma

  2. Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea

    So-Ra Yoon, Jae-Kook Cha, Jung-Seok Lee, Seong-Ho Choi & Ui-Won Jung

  3. Department of Periodontology, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea

    Hyun-Chang Lim

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  1. Daniel S. Thoma
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Corresponding author

Correspondence to Ui-Won Jung.

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Conflict of interest

The authors declare that they have no conflict of interest.

Funding

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science, ICT & Future Planning) (No. NRF-2017R1A2B2002537).

Ethical approval

This article does not contain any studies with human participants performed by any of the authors. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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For this type of study, formal consent is not required.

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Thoma, D.S., Yoon, SR., Cha, JK. et al. Sinus floor elevation using implants coated with recombinant human bone morphogenetic protein-2: micro-computed tomographic and histomorphometric analyses. Clin Oral Invest 22, 829–837 (2018). https://doi.org/10.1007/s00784-017-2158-3

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  • DOI: https://doi.org/10.1007/s00784-017-2158-3

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