The effects of a desiccant agent in the treatment of chronic periodontitis: a randomized, controlled clinical trial
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Chemotherapeutic agents have been widely used as adjuncts for the treatment of chronic periodontitis (CP). This study investigated and compared a desiccant agent as an adjunct to scaling and root planing (SRP) versus SRP alone for the treatment of CP.
Materials and methods
Thirty-six patients with CP were studied. Using a split-mouth design, the maxillary right and left quadrants were randomly assigned to SRP plus desiccant (Hybenx® EPIEN Medical, Inc. St. Paul, MN, USA) or SRP alone. Patients were examined on a regular basis for clinical, microbiological, and inflammatory mediator changes over a 1-year period. Clinical attachment level (CAL) was the primary outcome variable. In addition, the red complex bacteria and gingival crevicular fluid (GCF) inflammatory mediators were monitored.
Compared to baseline, both treatments demonstrated an improvement in periodontal parameters. Compared to SRP alone, SRP plus desiccant yielded a significant improvement in probing depth (PD) (SRP: 2.23 ± 0.31 mm vs. desiccant: 3.25 ± 0.57 mm, p < 0.05), CAL (SRP: 3.16 ± 0.29 mm vs. desiccant: 4.21 ± 0.34 mm, p < 0.05 mm) and bleeding on probing (BOP) (SRP: 4.56 ± 1.5% vs. desiccant: 34.23 ± 4.2%, p < 0.001) at 12 months. Similarly, in the SRP plus desiccant group, the bacteria of the red complex were significantly reduced (p < 0.05); and the level of inflammatory mediators was significantly reduced (p < 0.003) compared to SRP alone.
SRP plus the desiccant resulted in a greater reduction in clinical, microbial and inflammatory mediators compared to SRP alone.
Desiccant, when combined to SRP, was demonstrated as a significant approach to control the levels of certain periodontal pathogens, inflammatory mediators in patients with CP.
KeywordsChronic periodontitis Desiccants Local delivery Scaling and root planing Randomized controlled trials Microbiology
The authors would like to thank Dr. Giampaolo Menegazzi for his technical assistance, Dr. Simona Violi for her clinical assistance, and Dr. Rita Aveni of the University of Messina for her help in searching for literature.
This work has been performed with funding by the Department of Biomedical, Odontostomatological Sciences and Morphological and Functional Images, University of Messina, and confirm that all patients of this study were enrolled at the University of Messina, Italy.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The work was supported by the Department of Odontostomatology, School of Dentistry, University of Messina, Italy.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The local ethical committee of the University of Messina approved the study protocol (#919-10).
Informed consent was obtained from all individual participants included in the study.
- 2.Matarese G, Isola G, Anastasi GP, Cutroneo G, Favaloro A, Vita G, Cordasco G, Milardi D, Zizzari VL, Tetè S, Perillo L (2013) Effects of the transforming growth factor beta 1 and vascular endothelial growth factor expressions in the pathogenesis of periodontal disease. Eur J Inflamm 11:479–488CrossRefGoogle Scholar
- 3.Matarese G, Currò M, Isola G, Caccamo D, Vecchio M, Giunta ML, Ramaglia L, Cordasco G, Williams RC, Ientile R (2015) Transglutaminase 2 up-regulation is associated with RANKL/OPG pathway in cultured HPDL cells and THP-1-differentiated macrophages. Amino Acids 47:2447–2455CrossRefPubMedGoogle Scholar
- 11.Moreira AL, Novaes AB Jr, Grisi MF, Taba M Jr, Souza SL, Palioto DB, de Oliveira PG, Casati MZ, Casarin RC, Messora MR (2015) Antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of aggressive periodontitis: a split-mouth randomized controlled trial. J Periodontol 86:376–386CrossRefPubMedGoogle Scholar
- 14.Smiley CJ, Tracy SL, Abt E, Michalowicz BS, John MT, Gunsolley J, Cobb CM, Rossmann J, Harrel SK, Forrest JL, Hujoel PP, Noraian KW, Greenwell H, Frantsve-Hawley J, Estrich C, Hanson N (2015) Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J am Dent Assoc 146:508–524 e5CrossRefPubMedGoogle Scholar
- 29.Conover WJ (1999) Practical nonparametric statistics. John Wiley & Sons, Inc, New York: WileyGoogle Scholar
- 41.Arweiler NB, Pietruska M, Pietruski J, Skurska A, Dolińska E, Heumann C, Auschill TM, Sculean A (2014) Six-month results following treatment of aggressive periodontitis with antimicrobial photodynamic therapy or amoxicillin and metronidazole. Clin Oral Investig 18:2129–2135CrossRefPubMedGoogle Scholar
- 42.Air SP, Meghji S, Wilson M, Reddi K, White P, Henderson B (1996) Bacterially induced bone destruction: mechanisms and misconceptions. Infect Immun 64:2371–2380Google Scholar
- 49.Cutroneo G, Piancino MG, Ramieri G, Bracco P, Vita G, Isola G, Vermiglio G, Favaloro A, Anastasi G, Trimarchi F (2012) Expression of muscle-specific integrins in masseter muscle fibers during malocclusion disease. Int J Mol Med 30:235–42Google Scholar