Clinical Oral Investigations

, Volume 21, Issue 7, pp 2183–2188 | Cite as

Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: a prospective case-control study

  • Isabel MiclotteEmail author
  • Maarten Vanhaverbeke
  • Jimoh Olubanwo Agbaje
  • Paul Legrand
  • Thomas Vanassche
  • Peter Verhamme
  • Constantinus Politis
Original Article



The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions.

Materials and methods

This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure. A procedural bleeding score was recorded and early and delayed bleeding was assessed at day 1 and day 7. Bleeding events were compared with a prospectively matched control group not taking any antithrombotic drug.


There was no difference in the procedural bleeding score or in early bleeding events (5 in both groups). However, delayed bleeding occurred more frequently in anticoagulated compared to non-anticoagulated patients (7 versus none, p = 0.01).


Skipping the morning dose of NOACs avoids excess bleeding during and early after the procedure. However, anticoagulated patients had an increased risk of delayed bleedings. Further study is needed to determine the optimal post-procedural management.

Clinical relevance

This is the first prospective study for the management of patients on NOACs undergoing dental extraction. Our pragmatic approach, omitting only a single morning dose, can guide clinical practice. Both patients and physicians should be aware of the increased delayed bleeding risk.


Tooth extraction Anticoagulants New oral anticoagulants (NOACs) Interruption Bleeding 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


The work was supported by the Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Belgium.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial SurgeryUniversity Hospitals LeuvenLeuvenBelgium
  2. 2.Department of Cardiovascular MedicineUniversity Hospitals LeuvenLeuvenBelgium

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