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Clinical Oral Investigations

, Volume 21, Issue 1, pp 33–42 | Cite as

Serum antibody levels against Porphyromonas gingivalis in patients with and without rheumatoid arthritis – a systematic review and meta-analysis

  • Philip Bender
  • Walter B. Bürgin
  • Anton Sculean
  • Sigrun EickEmail author
Review

Abstract

Objectives

Since the peptidyl arginine deiminase of Porphyromonas gingivalis is able to citrullinate peptides and proteins, various studies have suggested the species as a possible link between periodontal disease (PD) and rheumatoid arthritis (RA). This systematic review including meta-analysis was aimed to evaluate whether differences in terms of antibody titers against P. gingivalis exist between RA patients and systemically healthy individuals with and without PD.

Materials and methods

The following focused question was addressed: Are the antibody titers against P. gingivalis of RA patients different from systemically healthy individuals with and without PD? A systematic data search was conducted in MEDLINE and EMBASE. The collected data underwent a meta-analysis to detect statistically significant differences in terms of antibody levels between the groups.

Results

From 114 articles found by the search 13 articles met the inclusion criteria and provided data suitable for meta-analysis. After analyzing various levels of confinement the meta-analysis revealed a statistically significant higher antibody titer against P. gingivalis in patients suffering from RA in comparison with systemically and periodontally healthy controls (p < 0.01) and systemically healthy patients with PD (p < 0.01).

Conclusion

The present findings indicate that RA is often accompanied by the presence of an immune response against P. gingivalis.

Clinical relevance

The significantly higher antibody response to P. gingivalis in comparison to systemically healthy individuals supports the link between PD and RA by P. gingivalis. Screening of the regularly taken blood samples of RA patients for P. gingivalis antibodies may help to sensitize rheumatologists and RA patients for improving periodontal health.

Keywords

Porphyromonas gingivalis Periodontal disease Rheumatoid arthritis Serum antibody levels 

Notes

Acknowledgments

The authors acknowledge the work of Bernadette Rawyler, School of Dental Medicine, Resort Multimedia, University of Bern, in preparing graphs.

Compliance with ethical standards

Funding

The study was funded by the European Commission (FP7-HEALTH-F3–2012-306,029 “TRIGGER”).

Conflict of interest

Author Philip Bender declares that he has no conflict of interest. Author Walter B. Bürgin declares that he has no conflict of interest. Author Anton Sculean declares that he has no conflict of interest. Author Sigrun Eick declares that she has no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study, formal consent is not required.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Periodontology, School of Dental MedicineUniversity of BernBernSwitzerland
  2. 2.Ressort ResearchUniversity of Bern, School of Dental MedicineBernSwitzerland

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