Oral manifestations of rheumatoid arthritis. A cross-sectional study of 73 patients
- 906 Downloads
A study is made of the main oral manifestations of patients with rheumatoid arthritis (RA), particularly salivary flow, and of its possible association to periodontal disease.
Material and methods
A prospective comparative study was made of 146 patients (73 with RA and 73 controls), recording pocket depth, clinical attachment loss, bleeding index, plaque index, and the DMFT index to assess periodontal and dental alterations. Sialometric measurements were also made to determine resting, stimulated, and parotid salivary flow.
The patients with RA had greater periodontal pocket depths (with moderate depths in most cases), as well as greater attachment loss and more bacterial plaque. The resting whole saliva and stimulated parotid saliva rates were also clearly decreased in the RA group compared with the controls.
Patients with RA are more likely to present periodontal disease, poorer oral hygiene manifesting as an increased accumulation of bacterial plaque, and decreased salivary flow rates.
Vulnerability to periodontitis is confirmed in one of the largest samples ever studied of patients with rheumatoid arthritis (RA). Also, there is evidence of hyposialia (decrease in salivary rate) in RA patients without Sjögren’s syndrome.
KeywordsRheumatoid arthritis Periodontal disease Dental caries Salivary flow Oral manifestations
Compliance with ethical standards
Conflict of interests
The authors declare that they have no competing interests.
The work was supported by the Unidad de Estomatología, Hospital Doctor Peset, Valencia.
This article does not contain any studies with human participants or animals performed by any of the authors.
For this type of study, formal consent is not required.
- 2.Helenius LM, Tervahartiala P, Helenius I, Al-Sukhun J, Kivisaari L, Suuronen R, et al. (2006) Clinical, radiographic and MRI findings of the temporomandibular joint in patients with different rheumatic diseases. Int J Oral Maxillofac Surg 35:983–989. doi: 10.1016/j.ijom.2006.08.001 CrossRefPubMedGoogle Scholar
- 8.Martinez-Martinez RE, Abud-Mendoza C, Patiño-Marin N, Rizo-Rodríguez JC, Little JW, Loyola-Rodríguez JP (2009) Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol 36:1004–1010. doi: 10.1111/j.1600-051X.2009.01496.x CrossRefPubMedGoogle Scholar
- 20.Havemose-Poulsen A, Sørensen LK, Bendtzen K, Holmstrup P (2007) Polymorphisms within the IL-1 gene cluster: effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol 78:475–492. doi: 10.1902/jop.2007.060135 CrossRefPubMedGoogle Scholar
- 25.Guobis Z, Baseviciene N, Paipaliene P, Niedzelskiene I, Januseviciūte G (2008) Aspects of xerostomia prevalence and treatment among rheumatic inpatients. Medicina (Kaunas) 44:960–968Google Scholar