Epulis: a study of 92 cases with special emphasis on histopathological diagnosis and associated clinical data
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Aim of the present study was clinical and histopathological evaluation of a series of epulides to provide clinicians data to frequency distribution and biological behaviour of different underlying entities.
Materials and methods
Ninety-two cases of epulides removed by CO2-laser at the Department of Oral Surgery and Radiology, Medical University of Graz from 2000 to 2014 were studied retrospectively for clinical data and histopathological diagnosis.
In the presented study, histopathological examination revealed peripheral ossifying fibroma (32.6 %), fibroma/fibrosis (29.3 %), giant cell lesion (13.1 %) and granuloma pyogenicum (8.7 %) as the most frequent underlying entities. For the first time, hyperplastic squamous epithelium (7.6 %), granulation tissue (5.4 %) and peripheral odontogenic fibromas (3.3 %) were detected to clinically appear as epulides. Irrespective of the histological diagnosis, the mean age in our patients was 43.8 years. The majority of the lesions were found in the frontal region of both jaws. In all cases, the patients showed poor oral hygiene, local gingivitis and some of them an occlusal trauma.
To identify different entities with different biological behaviour, to exclude malignant tumours and to identify new entities among epulides, histopathological examination is required. Poor oral hygiene and occlusal trauma seem to play an important role in the pathogenesis and could be risk factors for recurrences.
Frequency distribution of different entities in epulides is provided to clinicians, and new histopathological entities were detected to clinically appear as epulides.
KeywordsHyperplastic gingival lesions Reactive lesions Epulis Clinical data Histopathological entities
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
For this type of study, formal consent is not required.
- 3.Chaparro-Avendano AV, Berini-Aytes L, Gay Escoda C (2005) Peripheral giant cell granuloma. A report of five cases and review of the literature. Med Oral Patol Oral Cir Bucal 10(1):48–57Google Scholar
- 9.International Statistical Classification of Diseases and Related Health Problems 10th Revision (2015) ICD-10 WHO Version k 06.8Google Scholar
- 10.Tamarit-Borrás M, Delgado-Molina E, Berini-Aytés L, Gay-Escoda C (2005) Removal of hyperplastic lesions of the oral cavity. A retrospective study of 128 cases. Med Oral Patol Cir Bucal 10(2):151–162Google Scholar
- 13.Naderi NJ, Eshghyar N, Esfehanian H (2012) Reactive lesions of the oral cavitiy: a retrospective study on 2068 cases. Dent Res J 9(3):251–255Google Scholar
- 14.Kashyap B, Reddy PS, Nalini P (2012) Reactive lesions of oral cavitiy. A survey of 100 cases in Eluru. West Godavari District 3(3):294–297Google Scholar
- 20.Allerbeck M, Schlegel D, Triadan H (1960) Zum Zusammenhang zwischen Biss- und Parodontalbefunden bei Schwangeren unter besonderer Berücksichtigung hyperplastischer Parodontopathien. DZZ 15:813–817Google Scholar
- 22.Mutschelknauss R (1962) Klinisch morphologische Studie zur formalen Genese der Epulis. Stoma 15:170–184Google Scholar
- 23.Andrä A (1966) Die Formen der Epulis und ihre Behandlungen in der zahnärztlichen Ambulanz. Zahnärztekalender der DDR 226-236Google Scholar
- 30.Shadman N, Ebrahimi SF, Jafari S, Eslami M (2009) Peripheral giant cell granuloma: a review of 123 cases. Dent Res J 6(1):47–50Google Scholar
- 31.Vinay G, Mangala Gowri SR, Anbalagan J (2013) Sex determination of human mandible using metrical parameters. J Clin Diagn Res 7(12):2671–2673Google Scholar
- 34.Krishnapillai R, Punnoose K, Angadi PV, Koneru A (2012) Oral pyogenic granulma – a review of 215 cases in South Indian Teaching Hospital, Karnataka, over a period of 20 years. Oral Maxillofac Surg 16(3):305–309Google Scholar