Advertisement

Clinical Oral Investigations

, Volume 19, Issue 2, pp 181–191 | Cite as

Evaluation of the bone regeneration potential of bioactive glass in implant site development surgeries: a systematic review of the literature

  • Andreas L. Ioannou
  • Georgios A. KotsakisEmail author
  • Tarun Kumar
  • James E. Hinrichs
  • Georgios Romanos
Review

Abstract

Objectives

The aim of this systematic review was to assess the efficacy of bioactive glass (BG) in bone regeneration for implant site development procedures.

Material and methods

The following specific question was formulated with reference to Population, Intervention, Control, Outcomes (PICO): “In persons that undergo bone regeneration surgeries for implant site development, what histological outcomes does the use of BG yield, alone or in combination with AB, compared to positive or negative controls?”.

Results

The 1st phase of screening yielded 400 titles and abstracts. A total of 12 studies reporting on the use of bioactive glass were scrutinized for inclusion in the final analysis and 5 studies were selected for qualitative synthesis of the results. Data were divided into two categories: ridge preservation (n = 2) and sinus augmentation (n = 3).

Conclusions

Within the limitations of this review, it can be concluded that (1) the combination of BG with AB chips in a 1:1 ratio is an efficacious treatment modality for direct sinus augmentation, with histological results comparable to 100 % AB. (2) When used for ridge preservation, BG yields a high percentage of true bone regeneration. (3) Currently, no reliable controlled studies report histological outcomes from the use of BG in ridge augmentation procedures.

Clinical relevance

Clinicians may consider BG bone substitutes as efficacious alternatives for ridge preservation and sinus augmentation surgical procedures. Further controlled clinical studies are warranted to determine if bone-to-implant contact is improved in BG-grafted sites versus controls.

Keywords

Bioglass Bioactive glass Bone regeneration Bone substitutes Dental implants Systematic review 

Notes

Conflict of interest

The authors report no conflict of interest to this study.

References

  1. 1.
    Ishikawa T, Salama M, Funato A, Kitajima H, Moroi H, Salama H, Garber D (2010) Three-dimensional bone and soft tissue requirements for optimizing esthetic results in compromised cases with multiple implants. Int J Periodontics Restor Dent 30(5):503–511Google Scholar
  2. 2.
    Schropp L, Isidor F (2008) Timing of implant placement relative to tooth extraction. J Oral Rehabil 35(Suppl 1):33–43. doi: 10.1111/j.1365-2842.2007.01827.x CrossRefPubMedGoogle Scholar
  3. 3.
    Kotsakis G, Chrepa V, Marcou N, Prasad H, Hinrichs J (2012) Flapless alveolar ridge preservation utilizing the ''socket-plug'' technique: clinical technique and review of the literature. J Oral Implantol. doi: 10.1563/AAID-JOI-D-12-00028.1
  4. 4.
    Hansson S, Halldin A (2012) Alveolar ridge resorption after tooth extraction: a consequence of a fundamental principle of bone physiology. J Dent Biomech 3:1758736012456543. doi: 10.1177/1758736012456543 PubMedCentralPubMedGoogle Scholar
  5. 5.
    Block MS, Kent JN (1997) Sinus augmentation for dental implants: the use of autogenous bone. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 55(11):1281–1286CrossRefGoogle Scholar
  6. 6.
    Boyne PJ (2004) Augmentation of the posterior maxilla by way of sinus grafting procedures: recent research and clinical observations. Oral Maxillofac Surg Clin N Am 16(1):19–31. doi: 10.1016/j.coms.2003.10.006, v-viCrossRefGoogle Scholar
  7. 7.
    Winkler S (2002) Implant site development and alveolar bone resorption patterns. J Oral Implantol 28(5):226–229. doi: 10.1563/1548-1336 CrossRefPubMedGoogle Scholar
  8. 8.
    Kotsakis GA, Salama M, Chrepa V, Hinrichs JE, Gaillard P (2014) A randomized, blinded, controlled clinical study of particulate anorganic bovine bone mineral and calcium phosphosilicate putty bone substitutes for socket preservation. Int J Oral Maxillofac Implants 29(1):141–151. doi: 10.11607/jomi.3230 CrossRefPubMedGoogle Scholar
  9. 9.
    Kotsakis GA, Joachim FP, Saroff SA, Mahesh L, Prasad H, Rohrer MD (2014) Histomorphometric evaluation of a calcium-phosphosilicate putty bone substitute in extraction sockets. Int J Periodontics Restor Dent 34(2):233–239. doi: 10.11607/prd.1855 CrossRefGoogle Scholar
  10. 10.
    Barone A, Toti P, Piattelli A, Iezzi G, Derchi G, Covani U (2014) Extraction socket healing in humans after ridge preservation techniques: comparison between flapless and flapped procedures in a randomized clinical trial. J Periodontol 85(1):14–23. doi: 10.1902/jop.2013.120711 CrossRefPubMedGoogle Scholar
  11. 11.
    Thoma DS, Jones A, Yamashita M, Edmunds R, Nevins M, Cochran DL (2010) Ridge augmentation using recombinant bone morphogenetic protein-2 techniques: an experimental study in the canine. J Periodontol 81(12):1829–1838. doi: 10.1902/jop.2010.100161 CrossRefPubMedGoogle Scholar
  12. 12.
    Toloue SM, Chesnoiu-Matei I, Blanchard SB (2012) A clinical and histomorphometric study of calcium sulfate compared with freeze-dried bone allograft for alveolar ridge preservation. J Periodontol 83(7):847–855. doi: 10.1902/jop.2011.110470 CrossRefPubMedGoogle Scholar
  13. 13.
    Sbordone C, Toti P, Guidetti F, Califano L, Pannone G, Sbordone L (2013) Volumetric changes after sinus augmentation using blocks of autogenous iliac bone or freeze-dried allogeneic bone. A non-randomized study. J Cranio-Maxillofac Surg Off Publ Eur Assoc Cranio-Maxillofac Surg. doi: 10.1016/j.jcms.2013.03.004 Google Scholar
  14. 14.
    Wood RA, Mealey BL (2012) Histologic comparison of healing after tooth extraction with ridge preservation using mineralized versus demineralized freeze-dried bone allograft. J Periodontol 83(3):329–336. doi: 10.1902/jop.2011.110270 CrossRefPubMedGoogle Scholar
  15. 15.
    Fu JH, Wang HL (2011) Horizontal bone augmentation: the decision tree. Int J Periodontics Restor Dent 31(4):429–436Google Scholar
  16. 16.
    Misch CM (2010) Autogenous bone: is it still the gold standard? Implant Dent 19(5):361. doi: 10.1097/ID.0b013e3181f8115b CrossRefPubMedGoogle Scholar
  17. 17.
    Margonar R, Queiroz TP, Luvizuto ER, Marcantonio E, Lia RC, Holzhausen M, Marcantonio-Junior E (2012) Bioactive glass for alveolar ridge augmentation. J Craniofac Surg 23(3):e220–e222. doi: 10.1097/SCS.0b013e31824de5a4 CrossRefPubMedGoogle Scholar
  18. 18.
    Yilmaz S, Efeoglu E, Kilic AR (1998) Alveolar ridge reconstruction and/or preservation using root form bioglass cones. J Clin Periodontol 25(10):832–839CrossRefPubMedGoogle Scholar
  19. 19.
    Eldesoqi K, Seebach C, Nguyen Ngoc C, Meier S, Nau C, Schaible A, Marzi I, Henrich D (2013) High calcium bioglass enhances differentiation and survival of endothelial progenitor cells, inducing early vascularization in critical size bone defects. PLoS ONE 8(11):e79058. doi: 10.1371/journal.pone.0079058 CrossRefPubMedCentralPubMedGoogle Scholar
  20. 20.
    Stavropoulos A, Sima C, Sima A, Nyengaard J, Karring T, Sculean A (2012) Histological evaluation of healing after transalveolar maxillary sinus augmentation with bioglass and autogenous bone. Clin Oral Implants Res 23(1):125–131. doi: 10.1111/j.1600-0501.2011.02161.x CrossRefPubMedGoogle Scholar
  21. 21.
    Galindo-Moreno P, Avila G, Fernandez-Barbero JE, Mesa F, O’Valle-Ravassa F, Wang HL (2008) Clinical and histologic comparison of two different composite grafts for sinus augmentation: a pilot clinical trial. Clin Oral Implants Res 19(8):755–759. doi: 10.1111/j.1600-0501.2008.01536.x CrossRefPubMedGoogle Scholar
  22. 22.
    Hench LL (2006) The story of bioglass. J Mater Sci Mater Med 17(11):967–978. doi: 10.1007/s10856-006-0432-z CrossRefPubMedGoogle Scholar
  23. 23.
    Hench LL, Polak JM (2002) Third-generation biomedical materials. Science 295(5557):1014–1017. doi: 10.1126/science.1067404 CrossRefPubMedGoogle Scholar
  24. 24.
    Hench LL, Splinter RJ, Allen WC, Greenlee TK (1972) Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res Symp 5:117–141CrossRefGoogle Scholar
  25. 25.
    Hench LL, Wilson J (1986) Biocompatibility of silicates for medical use. CIBA Found Symp 121:231–246PubMedGoogle Scholar
  26. 26.
    Schepers E, de Clercq M, Ducheyne P, Kempeneers R (1991) Bioactive glass particulate material as a filler for bone lesions. J Oral Rehabil 18(5):439–452CrossRefPubMedGoogle Scholar
  27. 27.
    Xynos ID, Edgar AJ, Buttery LD, Hench LL, Polak JM (2001) Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution. J Biomed Mater Res 55(2):151–157CrossRefPubMedGoogle Scholar
  28. 28.
    Jell G, Notingher I, Tsigkou O, Notingher P, Polak JM, Hench LL, Stevens MM (2008) Bioactive glass-induced osteoblast differentiation: a noninvasive spectroscopic study. J Biomed MaterRes A 86(1):31–40. doi: 10.1002/jbm.a.31542 CrossRefGoogle Scholar
  29. 29.
    Sohrabi K, Saraiya V, Laage TA, Harris M, Blieden M, Karimbux N (2012) An evaluation of bioactive glass in the treatment of periodontal defects: a meta-analysis of randomized controlled clinical trials. J Periodontol 83(4):453–464. doi: 10.1902/jop.2011.110347 CrossRefPubMedGoogle Scholar
  30. 30.
    Richardson WS, Wilson MC, Nishikawa J, Hayward RS (1995) The well-built clinical question: a key to evidence-based decisions. ACP J Club 123(3):A12–A13PubMedGoogle Scholar
  31. 31.
    Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C, Porter AC, Tugwell P, Moher D, Bouter LM (2007) Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 7:10. doi: 10.1186/1471-2288-7-10 CrossRefPubMedCentralPubMedGoogle Scholar
  32. 32.
    Cohen JA (2001) A coefficient of agreement for nominal scales. Educ Psychol Meas 1960 20(1):37–46. doi: 10.1177/001316446002000104 CrossRefGoogle Scholar
  33. 33.
    Moher D, Schulz KF, Altman D, Group C (2001) The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA J Am Med Assoc 285(15):1987–1991CrossRefGoogle Scholar
  34. 34.
    Schwarz F, Aoki A, Becker J, Sculean A (2008) Laser application in non-surgical periodontal therapy: a systematic review. J Clin Periodontol 35(8 Suppl):29–44. doi: 10.1111/j.1600-051X.2008.01259.x CrossRefPubMedGoogle Scholar
  35. 35.
    Camargo PM, Lekovic V, Weinlaender M, Klokkevold PR, Kenney EB, Dimitrijevic B, Nedic M, Jancovic S, Orsini M (2000) Influence of bioactive glass on changes in alveolar process dimensions after exodontia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90(5):581–586. doi: 10.1067/moe.2000.110035 CrossRefPubMedGoogle Scholar
  36. 36.
    Canullo L, Dellavia C (2009) Sinus lift using a nanocrystalline hydroxyapatite silica gel in severely resorbed maxillae: histological preliminary study. Clin Implant Dent Relat Res 11(Suppl 1):e7–e13. doi: 10.1111/j.1708-8208.2008.00141.x CrossRefPubMedGoogle Scholar
  37. 37.
    Clozza E, Pea M, Cavalli F, Moimas L, Di Lenarda R, Biasotto M (2012) Healing of fresh extraction sockets filled with bioactive glass particles: histological findings in humans. Clin Implant Dent Relat Res. doi: 10.1111/j.1708-8208.2012.00463.x PubMedGoogle Scholar
  38. 38.
    Froum S, Cho SC, Rosenberg E, Rohrer M, Tarnow D (2002) Histological comparison of healing extraction sockets implanted with bioactive glass or demineralized freeze-dried bone allograft: a pilot study. J Periodontol 73(1):94–102. doi: 10.1902/jop.2002.73.1.94 CrossRefPubMedGoogle Scholar
  39. 39.
    Tadjoedin ES, de Lange GL, Holzmann PJ, Kulper L, Burger EH (2000) Histological observations on biopsies harvested following sinus floor elevation using a bioactive glass material of narrow size range. Clin Oral Implants Res 11(4):334–344CrossRefPubMedGoogle Scholar
  40. 40.
    Turunen T, Peltola J, Yli-Urpo A, Happonen RP (2004) Bioactive glass granules as a bone adjunctive material in maxillary sinus floor augmentation. Clin Oral Implants Res 15(2):135–141CrossRefPubMedGoogle Scholar
  41. 41.
    Scarano A, Degidi M, Iezzi G, Pecora G, Piattelli M, Orsini G, Caputi S, Perrotti V, Mangano C, Piattelli A (2006) Maxillary sinus augmentation with different biomaterials: a comparative histologic and histomorphometric study in man. Implant Dent 15(2):197–207. doi: 10.1097/01.id.0000220120.54308.f3 CrossRefPubMedGoogle Scholar
  42. 42.
    Mahesh L, Kotsakis G, Venkataraman N, Shukla S, Prasad H (2013) Ridge preservation with the socket-plug technique utilizing an alloplastic putty bone substitute or a particulate xenograft: a histological pilot study. J Oral Implantol. doi: 10.1563/AAID-JOI-D-13-00025 Google Scholar
  43. 43.
    Trombelli L, Heitz-Mayfield LJ, Needleman I, Moles D, Scabbia A (2002) A systematic review of graft materials and biological agents for periodontal intraosseous defects. J Clin Periodontol 29(Suppl 3):117–135, discussion 160–112CrossRefPubMedGoogle Scholar
  44. 44.
    Xynos ID, Hukkanen MV, Batten JJ, Buttery LD, Hench LL, Polak JM (2000) Bioglass 45S5 stimulates osteoblast turnover and enhances bone formation in vitro: implications and applications for bone tissue engineering. Calcif Tissue Int 67(4):321–329CrossRefPubMedGoogle Scholar
  45. 45.
    Varanasi VG, Owyoung JB, Saiz E, Marshall SJ, Marshall GW, Loomer PM (2011) The ionic products of bioactive glass particle dissolution enhance periodontal ligament fibroblast osteocalcin expression and enhance early mineralized tissue development. J Biomed Mater Res A 98(2):177–184. doi: 10.1002/jbm.a.33102 CrossRefPubMedGoogle Scholar
  46. 46.
    Klein M, Goetz H, Pazen S, Al-Nawas B, Wagner W, Duschner H (2009) Pore characteristics of bone substitute materials assessed by microcomputer tomography. Clin Oral Implants Res 20(1):67–74CrossRefPubMedGoogle Scholar
  47. 47.
    Al-Nawas B, Schiegnitz E (2014) Augmentation procedures using bone substitute materials or autogenous bone—a systematic review and meta-analysis. Eur J Oral Implantol 7:S219–S234PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Andreas L. Ioannou
    • 1
  • Georgios A. Kotsakis
    • 1
    Email author
  • Tarun Kumar
    • 2
  • James E. Hinrichs
    • 1
  • Georgios Romanos
    • 3
  1. 1.Advanced Education Program in PeriodontologyUniversity of MinnesotaMinneapolisUSA
  2. 2.Division of PeriodontologyBapuji Dental College and HospitalDavangereIndia
  3. 3.School of Dental MedicineStony Brook UniversityStony BrookUSA

Personalised recommendations