Clinical Oral Investigations

, Volume 18, Issue 3, pp 949–959 | Cite as

Use of endoscopy with narrow-band imaging system in detecting squamous cell carcinoma in oral chronic non-healing ulcers

  • Shih-Wei Yang
  • Yun-Shien Lee
  • Liang-Che Chang
  • Cheng-Cheng Hwang
  • Tai-An Chen
Original Article
First Online:
Received:
Accepted:

Abstract

Objectives

This study seeks to analyze the factors associated with the occurrence of squamous cell carcinoma in oral non-healing ulcers for more than 3 weeks and investigate the role of endoscopy with narrow-band imaging system (NBI) in detecting carcinoma in these lesions.

Methods

The demographic and clinicopathological data of patients receiving surgical interventions for chronic oral non-healing ulcers, and the intraepithelial papillary capillary loop patterns shown by NBI were retrospectively reviewed and analyzed.

Results

A total of 63 patients (41 males and 22 females) with mean age of 57.9 ± 16.7 years were enrolled. In univariate analysis, ulcers with induration, history of oral cancer, and intraepithelial microvasculature of NBI were factors associated with the occurrence of squamous cell carcinoma in oral non-healing ulcers. Multivariate analysis showed that the intraepithelial microvasculature of NBI was the only independent factor predicting the occurrence of carcinoma in oral chronic non-healing ulcers with sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 93.75 %, 91.49 %, 78.95 %, 97.73 %, and 92.06 %, respectively.

Conclusions

Morphology of intraepithelial microvasculature of NBI, or twisted, elongated, and destructive pattern of intraepithelial papillary capillary loop, is the only independent factor associated with the occurrence of squamous cell carcinoma in oral chronic non-healing ulcers. Endoscope with NBI is a rapid, safe, and promising tool in detecting squamous cell carcinoma in oral chronic non-healing ulcers.

Keywords

Chronic oral ulcer Non-healing Narrow-band imaging Carcinoma 
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Notes

Acknowledgments

The authors thank Yuan Yu Industry Co., Ltd, for technical support of the endoscope equipment and all the members of the Cancer Center, Chang Gung Memorial Hospital, Keelung, for their invaluable help.

Financial disclosure

a. There is no financial and material support for this research and work.

b. There are no financial interests the authors may have in companies or other entities that have an interest in the information in the Contribution (e.g., grants, advisory boards, employment, consultancies, contracts, honoraria, royalties, expert testimony, partnerships, or stock ownership in medically–related fields).

c. No funding body has influence on the paper or our decision to publish.

Conflict of interest

None

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Shih-Wei Yang
    • 1
    • 2
  • Yun-Shien Lee
    • 3
    • 4
  • Liang-Che Chang
    • 2
    • 5
  • Cheng-Cheng Hwang
    • 2
    • 5
  • Tai-An Chen
    • 1
    • 2
  1. 1.Department of Otolaryngology Head and Neck SurgeryChang Gung Memorial Hospital, KeelungKeelung 204Republic of China
  2. 2.School of MedicineChang Gung University College of MedicineTaoyuanRepublic of China
  3. 3.Genomic Medicine Research Core LaboratoryChang Gung Memorial HospitalTao-YuanRepublic of China
  4. 4.Department of BiotechnologyMing Chuan UniversityTao-YuanRepublic of China
  5. 5.Department of PathologyChang Gung Memorial HospitalKeelungRepublic of China

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