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Correlation between maxillofacial radiographic features and systemic severity as sickle cell disease severity predictor

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Abstract

This study was conducted to investigate the relationship among radiographic features observed on panoramic radiographs of sickle cell disease patients and analyze their relationship with history of systemic severity of the disease. Panoramic radiographs of 71 subjects with sickle cell disease were evaluated for the presence of the following radiographic bony alterations: radiopaque areas, increased spacing of bony trabeculae, horizontal arrangement of bony trabeculae and corticalization of mandibular canal. History of clinical systemic severity was assessed through direct questioning about the frequency of vaso-occlusive crisis, history of stroke, clinical jaundice, femur head necrosis, and leg ulceration. Chi-square or Fisher’s exact test were applied in order to analyze possible associations between radiographic features and history of complications, with p < 0.05 significance level. Increased spacing of bony trabeculae was statistically associated with absence of corticalization of mandibular canal (p < 0.01) and horizontal arrangement of bony trabeculae (p = 0.04). Statistically significant associations were demonstrated between history of clinical jaundice and presence of increased spacing of bony trabeculae (p = 0.02) and between history of stroke and presence of horizontal arrangement of bony trabeculae (p = 0.04). Based on the results of the current study, maxillofacial radiographic features may be associated with clinical parameters of systemic complications in sickle cell disease patients. The relationship between radiographic features and history of complications associated with clinical severity of sickle cell disease has not been demonstrated in the literature. Acknowledgment of such possible association may help establish prognosis and influence clinical treatment of systemic and oral complications.

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Acknowledgements

We are thankful to Professor Marilda Souza Gonçalves for carrying out the electrophoresis examinations in the Laboratory of Specialized Analysis in Hematology of School of Pharmacy of Federal University of Bahia. This study was supported by the Research Foundation of the State of Bahia (FAPESB).

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil

    Frederico Sampaio Neves

  2. Graduate Program of Interactive Processes of Organs and Systems, Institute of Health Science, Federal University of Bahia, Salvador, Bahia, Brazil

    Cristina Pinho Passos

  3. Department of Stomatology, Bauru Dental School, University of São Paulo, Bauru, São Paulo, Brazil

    Christiano Oliveira-Santos

  4. Department of Social Dentistry and Pediatrics, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil

    Maria Cristina Teixeira Cangussu

  5. Department of Oral and Maxillofacial Radiology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil

    Paulo Sérgio Flores Campos & Iêda Crusoé-Rebello

  6. Department of Biointeraction, Institute of Health Science, Federal University of Bahia, Salvador, Bahia, Brazil

    Roberto José Meyer Nascimento

  7. Department of Biomorphology, Institute of Health Science, Federal University of Bahia, Salvador, Bahia, Brazil

    Maria Isabela Guimarães Campos

  8. Departamento de Biomorfologia, Instituto de Ciências da Saúde, Av. Reitor Miguel Calmon, s/n°, Vale do Canela, CEP 40.110-902, Salvador, Bahia, Brazil

    Maria Isabela Guimarães Campos

Authors
  1. Frederico Sampaio Neves
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  2. Cristina Pinho Passos
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  3. Christiano Oliveira-Santos
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  4. Maria Cristina Teixeira Cangussu
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  5. Paulo Sérgio Flores Campos
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  6. Roberto José Meyer Nascimento
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  7. Iêda Crusoé-Rebello
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  8. Maria Isabela Guimarães Campos
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Corresponding author

Correspondence to Maria Isabela Guimarães Campos.

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Neves, F.S., Passos, C.P., Oliveira-Santos, C. et al. Correlation between maxillofacial radiographic features and systemic severity as sickle cell disease severity predictor. Clin Oral Invest 16, 827–833 (2012). https://doi.org/10.1007/s00784-011-0577-0

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  • DOI: https://doi.org/10.1007/s00784-011-0577-0

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