Clinical Oral Investigations

, Volume 15, Issue 6, pp 909–913 | Cite as

Clinical and antibacterial effect of an anti-inflammatory toothpaste formulation with Scutellaria baicalensis extract on experimental gingivitis

  • Nicole Birgit Arweiler
  • Gregory Pergola
  • Jana Kuenz
  • Elmar Hellwig
  • Anton Sculean
  • Thorsten Mathias Auschill
Original Article

Abstract

It was the aim of the study to evaluate the clinical and antibacterial effect of a dentifrice containing an anti-inflammatory plant extract (SB) versus a placebo (PLA) using an experimental gingivitis model. Forty subjects (20 per group) discontinued all oral hygiene measures for four teeth for a period of 21 days using a shield (to generate a possible gingivitis) while they could brush the other teeth normally. After brushing, the shield was removed and teeth were treated with the randomly assigned toothpaste slurry for 1 min. Löe and Silness gingival index (GI), Silness and Löe plaque index (PI), and biofilm vitality (VF%) were assessed at days 0, 14, and 21, respectively. Subjects of the PLA group developed a GI of 0.82 ± 0.342 (day 14) and 1.585 ± 0.218 (day 21), while the data of the SB group were significantly reduced (0.355 ± 0.243 and 0.934 ± 0.342, p < 0.001). While PI was significantly reduced at all follow-up appointments, reductions in VF reached the level of significance only at day 21. The results suggest that the new toothpaste formulation was able to significantly reduce the extent of gingivitis, plaque development, and vital flora.

Keywords

Experimental gingivitis Inflammation Dentifrice Plaque Biofilm vitality Clinical trial 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Nicole Birgit Arweiler
    • 1
  • Gregory Pergola
    • 2
  • Jana Kuenz
    • 2
  • Elmar Hellwig
    • 2
  • Anton Sculean
    • 3
  • Thorsten Mathias Auschill
    • 1
  1. 1.Department of PeriodontologyPhilipps-UniversityMarburgGermany
  2. 2.Department of Operative Dentistry and Periodontology, Dental School and Hospital FreiburgAlbert-Ludwigs-UniversityFreiburgGermany
  3. 3.Department of PeriodontologyUniversity of BerneBerneSwitzerland

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