Clinical effects of nanocrystalline hydroxyapatite paste in the treatment of intrabony periodontal defects: a randomized controlled clinical study
- 337 Downloads
The purpose of the present randomized controlled clinical study was to compare the clinical outcomes of papilla preservation flap surgery with or without the application of a novel nanocrystalline hydroxyapatite (nano-HA) bone graft substitute. Fourteen patients with paired intrabony periodontal defects of ≥4 mm participated in this split-mouth design study. The defects in each subject were randomly selected to receive nano-HA paste in conjunction with papilla preservation flaps or papilla preservation flaps alone. Probing bone levels (PBL) from a customized acrylic stent and probing pocket depths (PPD) were measured at baseline and again 6 months following surgery. No differences in any of the investigated parameters were observed at baseline between the two groups. Healing was uneventful in all patients. Both treatments resulted in significant improvements between baseline and 6 months (p < 0.05). At 6 months after therapy, the sites treated with nano-HA paste showed a reduction in mean PPD from 8.3 ± 1.2 to 4.0 ± 1.1 mm and a gain in PBL of 4.3 ± 1.4 mm, whereas in the control group, the mean PPD changed from 7.9 ± 1.2 mm to 5.0 ± 1.2 mm and PBL gain was 2.6 ± 1.4 mm. Results demonstrated statistically greater PPD reduction and PBL gain (p < 0.05) in the test group as compared with the control group. In conclusion, after 6 months, the treatment of intrabony periodontal defects with a nano-HA paste leads to significantly improved clinical outcomes when compared with papilla preservation flap surgery alone.
KeywordsNanostructured hydroxyapatite Grafts Intrabony defects Periodontal regeneration Periodontal diseases
Conflict of interest
The authors declare that they have no conflict of interest.
- 13.Bezrukov VM, Grigor’iants LA, Zuev VP, Pankratov AS (1998) The surgical treatment of jaw cysts using hydroxyapatite with an ultrahigh degree of dispersity. Stomatologiia (Mosk) 77:31–35Google Scholar
- 15.Huber FX, Mcarthur N, Hillmeier J, Kock HJ, Baier M, Diwo M, Berger I, Meeder PJ (2006) Void filling of tibia compression fracture zones using a novel resorbable nanocrystalline hydroxyapatite paste in combination with a hydroxyapatite ceramic core: first clinical results. Arch Orthop Trauma Surg 126:533–540CrossRefPubMedGoogle Scholar
- 16.Grigor’ian AS, Grigor’iants LA, Podoinikova MN (2000) A comparative analysis of the efficacy of different types of filling materials in the surgical elimination of tooth perforations (experimental morphological research). Stomatologiia (Mosk) 79:9–12Google Scholar
- 18.Schwarz F, Bieling K, Latz T, Nuesry E, Becker J (2006) Healing of intrabony peri-implantitis defects following application of a nanocyrstalline hydroxyapatite (Ostim™) or a bovine-derived xenograft (Bio-Oss™) in combination with a collagen membrane (Bio-Gide™). A case series. J Clin Periodontol 33:491–499CrossRefPubMedGoogle Scholar
- 20.Zuev VP, Dmitrieva LA, Pankratov AS, Filatova NA (1996) The comparative characteristics of stimulators of reparative osteogenesis in the treatment of periodontal diseases. Stomatologiia (Mosk) 75:31–34Google Scholar
- 22.Cortellini P, Pini Prato GP, Tonetti M (1995) The modified papilla preservation technique. A new surgical approach for interproximal regenerative procedures. J Periodontol 66:217–223Google Scholar
- 36.Horvath A, Stavropoulos A, Sculean A (2009) Clinical and histological evaluation of human intrabony periodontal defects treated with an unsintered nanocrystalline hydroxyapatite paste (Ostim®). J Clin Periodontol 36:116Google Scholar
- 38.Schnettler R, Dingeldein E (2002) Inorganic bone substitutes. In: Lewandrowski KU, Wise DL, Trantolo DJ, Gresser JD, Yaszemski MJ, Altobelli DE (eds) Tissue engineering and biodegradable equivalents: scientific and clinical applications. Marcell Dekker, Inc., New York, pp 401–432Google Scholar
- 40.Schnettler R, Stahl JP, Alt V, Pavlidis T, Dingeldein E, Wenisch S (2004) Calcium phosphate-based bone substitutes. Eur J Trauma 4:219–229Google Scholar