Advertisement

Clinical Oral Investigations

, Volume 10, Issue 3, pp 205–209 | Cite as

Oral verrucous carcinoma: a retrospective study in São Paulo Region, Brazil

  • Denise Tostes OliveiraEmail author
  • Renato Vieira de Moraes
  • Jorge Francisco Fiamengui Filho
  • João Fanton Neto
  • Gilles Landman
  • Luiz Paulo Kowalski
Original Article

Abstract

Oral verrucous carcinoma (OVC) is a rare variant of squamous cell carcinoma with a characteristic morphology and specific behavior. To date, few studies are available focusing the prevalence and clinicopathologic features of the oral verrucous carcinoma in Brazilian population. A total of 3,500 primary oral well-differentiated squamous cell carcinoma surgically excised in the A.C. Camargo Cancer Hospital and Amaral Carvalho Cancer Hospital, Brazil, from 1980 to 2000 were retrospectively reviewed. Twenty cases of verrucous carcinomas were identified, most of them occurring in older male with age above the sixth decade, the sites frequently affected being the lower lip and the hard palate. Microscopically, the tumor showed a heavily keratinized lesion with compressive invasion pattern, little atypia, and free surgical margins. The local recurrence was verified in 38.5% of the patients with oral verrucous carcinoma; however, regional recurrence and distant metastasis were not verified. The results suggest that, although it is less frequent and with excellent prognosis, the verrucous carcinoma presents a potential for local recurrence that should be considered during the surgical planning of this neoplasm in the oral cavity.

Keywords

Verrucous carcinoma Oral squamous cell carcinoma Oral cancer Verrucous lesion Prognosis 

Notes

Acknowledgements

The authors thank FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo, grant 03/14141-3) and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) for supporting this study.

References

  1. 1.
    Ackerman LV (1948) Verrucous carcinoma of the oral cavity. Surgery 23:670–678PubMedGoogle Scholar
  2. 2.
    Bouquot JE (1998) Oral verrucous carcinoma: incidence in two US populations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86:318–324PubMedCrossRefGoogle Scholar
  3. 3.
    Castro AL et al (1991) Carcinoma verrucoso. Rev Cient UNOESTE 11:75–81Google Scholar
  4. 4.
    Chagin AL (2000) Factores de riesgo etiopatogenicos del carcinoma verrugoso en cavidad bucal. Acta Odontol Venez 38:9–14Google Scholar
  5. 5.
    Demian SDE, Bushkin FL, Echevarria RA (1973) Perineural invasion and anaplastic transformation of verrucous carcinoma. Cancer 32:395–401PubMedCrossRefGoogle Scholar
  6. 6.
    Eisenberg E, Rosenberg B, Krutchkoff DJ (1985) Verrucous carcinoma: a possible viral pathogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 59:52–57Google Scholar
  7. 7.
    Ferlito A, Rinaldo A, Mannarà GM (1998) Is primary radiotherapy an appropriate option for the treatment of verrucous carcinoma of the head and neck? J Laryngol Otol 112:132–139PubMedGoogle Scholar
  8. 8.
    Ferlito A et al (1999) Papillary squamous cell carcinoma versus verrucous squamous cell carcinoma of the head and neck. Ann Otol Rhinol Laryngol 108:318–322PubMedGoogle Scholar
  9. 9.
    Figueiredo MAZ et al (1991) Carcinoma verrucoso. Apresentação de casos. Rev Odonto Cienc 2:63–74Google Scholar
  10. 10.
    Jacobson S, Shear M (1972) Verrucous carcinoma of the mouth. J Oral Pathol 1:66–75PubMedCrossRefGoogle Scholar
  11. 11.
    Jyothirmayi R et al (1997) Radiotherapy in the treatment of verrucous carcinoma of the oral cavity. Oral Oncol 33:124–128PubMedCrossRefGoogle Scholar
  12. 12.
    Kaugars GE et al (1999) Oral verrucous carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87:268–269PubMedGoogle Scholar
  13. 13.
    Koch BB et al (2001) National survey of head and neck verrucous carcinoma. Cancer 92:110–120PubMedCrossRefGoogle Scholar
  14. 14.
    Kraus F, Perez-Mesa C (1966) Verrucous carcinoma—clinical and pathologic study of 105 cases involving oral cavity, larynx and genitalia. Cancer 19:26–38PubMedCrossRefGoogle Scholar
  15. 15.
    Link JO, Kaugars GE, Burns JC (1992) Comparison of oral carcinomas in smokeless tobacco users and nonusers. J Oral Maxillofac Surg 50:452–455PubMedCrossRefGoogle Scholar
  16. 16.
    Lübbe J et al (1996) HPV-11 and HPV-16 associated oral verrucous carcinoma. Dermatology 192:217–221PubMedCrossRefGoogle Scholar
  17. 17.
    McCoy JM, Waldron CA (1981) Verrucous carcinoma of the oral cavity. A review of forty-nine cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 52:623–629Google Scholar
  18. 18.
    Mirbod SM, Ahing SI (2000) Tobacco-associated lesions of the oral cavity: part II. Malignant lesions. J Can Dent Assoc 66:308–311PubMedGoogle Scholar
  19. 19.
    Noble-Topham SE et al (1993) Detection and typing of human papillomavirus in verrucous carcinoma of the oral cavity using the polymerase chain reaction. Arch Otolaryngol Head Neck Surg 119:1299–1304PubMedGoogle Scholar
  20. 20.
    Rajendran R et al (1988) Ackerman’s tumour (verrucous carcinoma) of the oral cavity: a clinico-epidemiologic study of 426 cases. Aust Dent J 33:295–298PubMedCrossRefGoogle Scholar
  21. 21.
    Rajendran R et al (1989) Ackerman’s tumour (Verrucous carcinoma) of the oral cavity: a histopathologic study of 426 cases. Singap Dent J 14:48–53Google Scholar
  22. 22.
    Santana Filho M, Rovani G (2000) Avaliação quantitativa das células de Langerhans no carcinoma verrucoso e no epitélio normal adjacente. Rev Pós-Grad 7:225–229Google Scholar
  23. 23.
    Spiro R (1998) Verrucous carcinoma, then and now. Am J Surg 176:393–397PubMedCrossRefGoogle Scholar
  24. 24.
    Sundström B; Mörnstad H; Axéll T (1982) Oral carcinomas associated with snuff dipping. Some clinical and histological characteristics of 23 tumours in Swedish males. J Oral Pathol 11:245–51PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Denise Tostes Oliveira
    • 1
    Email author
  • Renato Vieira de Moraes
    • 1
  • Jorge Francisco Fiamengui Filho
    • 1
  • João Fanton Neto
    • 2
  • Gilles Landman
    • 3
  • Luiz Paulo Kowalski
    • 4
  1. 1.Department of Stomatology, Area of Pathology, Bauru School of DentistryUniversity of São PauloBauruBrazil
  2. 2.Amaral Carvalho Cancer HospitalJaúBrazil
  3. 3.Department of PathologyA. C. Camargo Cancer HospitalSão PauloBrazil
  4. 4.Department of Head and Neck Surgery and OtorhinolaryngologyA. C. Camargo Center HospitalSão PauloBrazil

Personalised recommendations