Molecules Online

, Volume 2, Issue 1, pp 58–62 | Cite as

Novel, Amino Acid-Derived Heterobicycles: Scaffolds for β-Turn Mimics and Targets for Combinatorial Synthesis

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Abstract

Interest in combinatorial synthetic design and in α-turn mimics led to the development of a short synthesis of three ring systems (1—3) from cyclization of hydroxyacyl-dipeptide aldehyde derivatives, 6—8, with trifluoroacetic acid in acetone. The bicyclic products 1 and 2 were formed as single diastereomers with the benzyl substituent in the exo orientation, as determined by X-ray crystallography; the benzo analogs 3 were formed as mixtures of epimers, with the endo isomers predominating.

Keywords

Peptide acetals Peptidomimetics X-ray crystallography 

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Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  1. 1.Department of ChemistryContra Costa CollegeSan PabloUSA
  2. 2.Department of ChemistryUniversity of CaliforniaBerkeleyUSA

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