Metallocenter assembly in nickel-containing enzymes

  • Robert P. Hausinger


 The five known nickel-dependent enzymes include urease, hydrogenase, carbon monoxide dehydrogenase (and CO dehydrogenase/acetyl-coenzyme A synthase), methyl-S–coenzyme M reductase, and one class of superoxide dismutase. Consistent with their disparate functions, these Ni enzymes have distinct metallocenter structures that vary in Ni coordination geometry, number and types of metals, and the presence of additional components. Sophisticated cellular Ni processing systems have been devised to allow for specific and functional incorporation of Ni into these proteins. This review highlights several themes that are common to the enzyme activation processes and summarizes current concepts related to the enzyme-specific Ni assembly pathways.

Key words Nickel enzymes Metal Transport Metallochaperone Metal shuttle Accessory protein 


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Copyright information

© Society of Biological Inorganic Chemistry 1997

Authors and Affiliations

  • Robert P. Hausinger
    • 1
  1. 1.Departments of Microbiology and Biochemistry, 160 Giltner Hall, Michigan State University, East Lansing, MI 48824–1101, USAUS

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