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Peroxygenase reactions catalyzed by cytochromes P450

  • Osami Shoji
  • Yoshihito Watanabe
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Part of the following topical collections:
  1. Topical Issue in honor of Ivano Bertini

Abstract

Cytochromes P450 (P450s) catalyze monooxygenation of a wide range of less reactive organic molecules under mild conditions. By contrast with the general reductive oxygen activation pathway of P450s, an H2O2-shunt pathway does not require any supply of electrons and protons for the generation of a highly reactive intermediate (compound I). Because the low cost of H2O2 allows us to use it in industrial-scale synthesis, the H2O2-shunt pathway is an attractive process for monooxygenation reactions. This review focuses on the P450-catalyzed monooxygenation of organic molecules using H2O2 as the oxidant.

Keywords

Cytochrome Heme X-ray crystallography Site-directed mutagenesis Dioxygen 

Notes

Acknowledgments

This work was supported, in part, by a Grant-in-Aid for Scientific Research (S) to Y. W. (24225004), a Grant-in-Aid for Young Scientists (A) to O. S. (21685018), and a Grant-in-Aid for Scientific Research on Innovative Areas “Molecular Activation Directed Toward Straightforward Synthesis” to O.S. (25105724) from the Ministry of Education, Culture, Sports, Science, and Technology (Japan).

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Copyright information

© SBIC 2014

Authors and Affiliations

  1. 1.Department of Chemistry, Graduate School of ScienceNagoya UniversityNagoyaJapan
  2. 2.Research Center for Materials ScienceNagoya UniversityNagoyaJapan

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