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Alkylating ability of artemisinin after Cu(I)-induced activation

  • Fatima Bousejra-El Garah
  • Marguerite Pitié
  • Laure Vendier
  • Bernard Meunier
  • Anne RobertEmail author
Original Paper

Abstract

The reductive activation of artemisinin by copper(I)-dipyrrin or copper(I)-(2-Clip-Phen) complexes generates an artemisinin derived alkylating species leading to covalent artemisinin–copper complex adducts. The reactivity of the peroxide function of artemisinin toward Cu(I) complexes is similar to that of Fe(II) analogues, even though the reaction is more sluggish and product distribution slightly different.

Keywords

Alkylation Artemisinin Copper Malaria Non-heme complexes 

Notes

Acknowledgments

This work was supported by Palumed Co. and ANR (ANR-06-RIB-020-02). F.B.-E.G. is indebted to the Antimal program (EU-PF6) for Doctoral fellowship. The authors also thank F. Coslédan (Palumed Co.) for fruitful discussion, and Y. Coppel and C. Claparols (LCC-CNRS) for NMR and MS analyses, respectively.

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Copyright information

© SBIC 2009

Authors and Affiliations

  • Fatima Bousejra-El Garah
    • 1
  • Marguerite Pitié
    • 1
  • Laure Vendier
    • 1
  • Bernard Meunier
    • 2
  • Anne Robert
    • 1
    Email author
  1. 1.Laboratoire de Chimie de Coordination du CNRSToulouse cedex 4France
  2. 2.Palumed, 3 rue de l’IndustrieCastanet-TolosanFrance

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