Control of redox reactivity of flavin and pterin coenzymes by metal ion coordination and hydrogen bonding



The electron-transfer activities of flavin and pterin coenzymes can be fine-tuned by coordination of metal ions, protonation and hydrogen bonding. Formation of hydrogen bonds with a hydrogen-bond receptor in metal–flavin complexes is made possible depending on the type of coordination bond that can leave the hydrogen-bonding sites. The electron-transfer catalytic functions of flavin and pterin coenzymes are described by showing a number of examples of both thermal and photochemical redox reactions, which proceed by controlling the electron-transfer reactivity of coenzymes with metal ion binding, protonation and hydrogen bonding.


Cofactor Electron transfer Photoreduction Flavin Pterin 



The authors gratefully acknowledge the contributions of their collaborators and coworkers mentioned in the references. The authors acknowledge continuous support of their study by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan.


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© SBIC 2008

Authors and Affiliations

  1. 1.Department of Material and Life Science, Graduate School of EngineeringOsaka University, SORST, Japan Science and Technology AgencySuita, OsakaJapan

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