JBIC Journal of Biological Inorganic Chemistry

, Volume 13, Issue 3, pp 321–333

Control of redox reactivity of flavin and pterin coenzymes by metal ion coordination and hydrogen bonding

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Abstract

The electron-transfer activities of flavin and pterin coenzymes can be fine-tuned by coordination of metal ions, protonation and hydrogen bonding. Formation of hydrogen bonds with a hydrogen-bond receptor in metal–flavin complexes is made possible depending on the type of coordination bond that can leave the hydrogen-bonding sites. The electron-transfer catalytic functions of flavin and pterin coenzymes are described by showing a number of examples of both thermal and photochemical redox reactions, which proceed by controlling the electron-transfer reactivity of coenzymes with metal ion binding, protonation and hydrogen bonding.

Keywords

Cofactor Electron transfer Photoreduction Flavin Pterin 

Copyright information

© SBIC 2008

Authors and Affiliations

  1. 1.Department of Material and Life Science, Graduate School of EngineeringOsaka University, SORST, Japan Science and Technology AgencySuita, OsakaJapan

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