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Journal of Bone and Mineral Metabolism

, Volume 17, Issue 2, pp 113–118 | Cite as

Urinary pyridinoline and deoxypyridinoline as bone metabolic markers in predicting therapeutic effects of estrogen and alfacalcidol in women with osteoporosis

  • Zhiwei Zhan
  • Itsuo Yamamoto
  • Rikushi Morita
  • Hiroaki Miura

Abstract:

The purpose of the present study was to evaluate the clinical usefulness of urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) in predicting therapeutic effects of estrogen and alfacalcidol (1α-D3) in patients with postmenopausal osteoporosis. We measured urinary excretion of Pyr and Dpyr, and determined bone mineral density (BMD) using a dual-energy x-ray absorptiometry in 48 women with osteoporosis (average age, 55.9 ± 8.4 years). Patients were treated with estrogen (HRT, n = 13), 1α-D3 (n = 20), or calcium alone (n = 15). Baseline mean levels of urinary Pyr and Dpyr were significantly higher in the 48 patients compared to those in the age-matched postmenopausal women. The levels of urinary Pyr and Dpyr were inversely correlated with BMD. After treatment with estrogen or 1α-D3, a significant decrease of urinary Pyr and Dpyr was observed, and elevated urinary Pyr and Dpyr were reduced to the level in premenopausal women. A significant inverse correlation was found in Pyr and Dpyr at 6 months and in lumbar BMD after 24 months of treatment (r = −0.43 to −0.52; P < 0.01). We concluded that urinary Pyr and Dpyr have clinical utility for predicting response to estrogen and 1α-D3 therapy of osteoporosis patients.

Key words: pyridinoline deoxypyridinoline postmenopausal osteoporosis HRT 1α-hydroxyvitamin D3 

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Copyright information

© Springer-Verlag Tokyo 1999

Authors and Affiliations

  • Zhiwei Zhan
    • 1
  • Itsuo Yamamoto
    • 2
  • Rikushi Morita
    • 2
  • Hiroaki Miura
    • 3
  1. 1.Department of Endocrinology, Xiao Xi Tian No. 262 Hospital, Beijing, ChinaCN
  2. 2.Department of Radiology, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520-2192, JapanJP
  3. 3.Hikone Research Laboratories, Maruho Co. Ltd., Hikone, JapanJP

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