Change of skeletal muscle mass in patients with pheochromocytoma
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The effects of catecholamine excess due to pheochromocytoma on body composition, including skeletal muscle mass, are unknown. Here, we investigated the effects of catecholamine metabolites on body composition in subjects with pheochromocytoma. After body compositions using bioelectrical impedance analysis, urinary metanephrine (UM), and urinary normetanephrine (UNM) were measured in 16 patients with pheochromocytoma and 224 patients with nonfunctioning adrenal incidentaloma (NFAI), we compared skeletal muscle mass and fat mass (FM) between the two groups. After adjustments for confounders, UM (β = − 0.171, P = 0.006) and UNM (β = − 0.249, P < 0.001) levels were correlated inversely with skeletal muscle mass index (SMI), but not FM or percentage FM (pFM), in all subjects. Patients with pheochromocytoma had lower ASM by 7.7% (P = 0.022) and SMI by 6.6% (P = 0.001) than patients with NFAI. Conversely, FM and pFM were not statistically different between the two groups. The odds ratio for low skeletal muscle mass in the presence of pheochromocytoma was 10.33 (95% confidence interval, 2.65–40.22). Our results indicate that patients with pheochromocytoma have a reduced skeletal muscle mass and suggest that catecholamine excess has adverse effects on skeletal muscle metabolism.
KeywordsPheochromocytoma Catecholamine Skeletal muscle Sarcopenia
JHK and BJK should be considered senior authors. JHK and BJK had full access to all of the data in the study and take responsibility for the integrity of the data and accuracy of the data analysis. SHL, JHK, and BJK were involved in study conception or design. SHL performed data analysis or interpretation. MKK, SHA, HK, YYC, SS, KHS, and JMK performed data acquisition. SHL, JHK, and BJK were involved in drafting and critical revision of the manuscript for intellectual content. All authors, SHL, MKK, SHA, HK, YYC, SS, KHS, JMK, JHK, and BJK, evaluated the data, reviewed the manuscript, and approved the submission of the manuscript
This study was supported by a grant from the Asan Institute for Life Sciences (Seoul, Korea, project no. 2018-568), from Dong-A ST (Seoul, Korea, project no. 2011-04-090), and from the Bio & Medical Technology Development Program of the National Research Foundation, funded by the Korean government, MSIP (project no. 2016M3A9E8941329)
Compliance with ethical standards
Conflict of interest
The authors report no potential conflicts of interest.
Research involving human participants
All procedures involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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