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Osteoporosis and vertebral fracture are associated with deterioration of activities of daily living and quality of life in patients with type 2 diabetes mellitus

  • Ippei KanazawaEmail author
  • Ayumu Takeno
  • Ken-ichiro Tanaka
  • Yuko Yamane
  • Toshitsugu Sugimoto
Original Article

Abstract

Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fracture. However, whether diabetes-related osteoporosis independently contributes to the deterioration of activities of daily living (ADLs) and quality of life (QOL) is unclear. This cross-sectional study investigated the association between osteoporosis, ADLs, and QOL in 309 patients with T2DM. ADLs and QOL were assessed using Barthel Index (BI) and a SF-36 questionnaire. Multiple logistic regression analyses adjusted for age, gender, T2DM duration, body mass index, hemoglobin A1c, estimated GFR, diabetic neuropathy, retinopathy, nephropathy, cardiovascular disease, cerebrovascular disease, peripheral artery disease, and anti-diabetic treatments were conducted. The number of patients with osteoporosis or vertebral fracture was 166 (53.7%) and 118 (38.2%), respectively. Osteoporosis was significantly associated with lower general health (GH), social functioning (SF), and role emotional (RE) (OR 2.56, 1.79, and 1.92, respectively; all p values < 0.05 at least) and marginally associated with lower BI (OR 2.39, p = 0.068). Moreover, the presence of vertebral fracture grade 2 or 3 was significantly associated with lower BI, bodily pain (BP), GH, vitality, SF, and RE (OR 2.58, 2.01, 3.64, 1.99, 2.18, and 1.97, respectively; all p values < 0.05 at least). Osteoporosis and severe vertebral fracture were associated with the deterioration of ADLs and QOL independently of other diabetic complications. Therefore, the management of diabetes-related osteoporosis is an important strategy to avoid the deterioration of ADLs and QOL in T2DM.

Keywords

Type 2 diabetes mellitus Osteoporosis Vertebral fracture ADLs QOL 

Abbreviations

ADLs

Activities of daily living

BI

Barthel Index

BMD

Bone mineral density

BMI

Body mass index

BP

Bodily pain

eGFR

Estimated glomerular filtration rate

GH

General health

HbA1c

Hemoglobin A1c

MH

Mental health

PAD

Peripheral arery disease

PF

Physical functioning

RE

Role emotional

RP

Role physical

SF

Social functioning

QOL

Quality of life

T2DM

Type 2 diabetes mellitus

VT

Vitality

YAM

Young adult mean

Notes

Acknowledgements

The authors are grateful to the patients and hospital staff who participated in this study. This study was funded by the Japan Osteoporosis Foundation and partly supported by research Grant from Eli Lilly Japan. I.K. is fully responsible for the content of the manuscript.

Author contributions

IK collected and analysed the data and prepared the manuscript. AT, KT, and YY collected the data. TS contributed to the discussion and reviewed the manuscript. All authors participated in the preparation of the manuscript and approved its final version for publication.

Funding

This study was funded by the Japan Osteoporosis Foundation.

Compliance with ethical standards

Conflict of interest

Ippei Kanazawa, Ayumu Takeno, Ken-ichiro Tanaka, Yuko Yamane and Toshitsugu Sugimoto declare that they have no conflicts of interest.

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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Internal Medicine 1, Faculty of MedicineShimane UniversityIzumoJapan
  2. 2.Masuda Red Cross HospitalMasudaJapan
  3. 3.Yamane HospitalHamadaJapan

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