Skip to main content
SpringerLink
Log in

Optimal vitamin D intake for preventing serum 25-hydroxyvitamin D insufficiency in young Japanese women

  • Original Article
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Populations of East Asian countries have been known to have low calcium intakes and low serum 25(OH)D concentrations, suggesting that Ca and vitamin D (VitD)-deficiencies are commonly observed. These nutritional imbalances may lead to low peak bone mass (PBM). The low PBM seen in Ca/VitD-deficient individuals may lead to osteoporosis, as well as an increased risk of fracture. A survey was conducted in young Japanese women (n = 296, 21.2 ± 2.3 years old) on their Ca/VitD intakes and serum 25(OH)D levels, which demonstrated a significant positive correlation between VitD intake and serum 25(OH)D levels (R 2 = 0.020, P = 0.016), and the proportion with serum 25(OH)D over 20 ng/mL was significantly increased with VitD intake (P = 0.013). Serum 25(OH)D was negatively correlated to serum intact parathyroid hormone (R 2 = 0.053, P < 0.001). On receiver operating characteristic curve analysis, the VitD intake threshold for maintaining 25(OH)D levels at 20 ng/mL or higher was 11.6 μg/day or greater. It was suggested that the recommended VitD intake allowance, defined in the Adequate Intakes as 5.5 μg/day, may not be sufficient to maintain serum 25(OH)D levels for bone health.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Ohta H, Uenishi K, Shiraki M (2016) Recent nutritional trends of calcium and vitamin D in East Asia. Osteoporos Sarcopenia 4:208–213

    Article  Google Scholar 

  2. Weaver CM, Gordon CM, Janz KF, Kalkwarf HJ, Lappe JM, Lewis R, O’Karma M, Wallace TC, Zemel BS (2016) The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations. Osteoporos Int 27:1281–1386

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine Society (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930

    Article  PubMed  CAS  Google Scholar 

  4. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium (2011). In: Ross AC, Taylor CL, Yaktine AL, Del Valle HB (eds) Dietary reference intakes for calcium and vitamin D. National Academies Press (US), Washington DC

    Google Scholar 

  5. Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GE, Josse RG, Lips P, Morales-Torres J, Yoshimura N (2010) IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 21:1151–1154

    Article  PubMed  CAS  Google Scholar 

  6. Hanley DA, Cranney A, Jones G, Whiting SJ, Leslie WD, Cole DE, Atkinson SA, Josse RG, Feldman S, Kline GA, Rosen C, Guidelines Committee of the Scientific Advisory Council of Osteoporosis Canada (2010) Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada. CMA 182:E610–E618

    Article  Google Scholar 

  7. Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, Lindsay R, Foundation National Osteoporosis (2014) Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int 25:2359–2381

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Tsugawa N, Uenishi K, Ishida H, Ozaki R, Takase T, Minekami T, Uchino Y, Kamao M, Okano T (2016) Association between vitamin D status and serum parathyroid hormone concentration and calcaneal stiffness in Japanese adolescents: sex differences in susceptibility to vitamin D deficiency. J Bone Miner Metab 34:464–474

    Article  PubMed  CAS  Google Scholar 

  9. Ohta H, Uemura Y, Nakamura T, Fukunaga M, Ohashi Y, Hosoi T, Mori S, Sugimoto T, Itoi E, Orimo H, Shiraki M, Adequate Treatment of Osteoporosis (A-TOP) Research Group (2014) Serum 25-hydroxyvitamin D level as an independent determinant of quality of life in osteoporosis with a high risk for fracture. Clin Ther 36:225–235

    Article  PubMed  CAS  Google Scholar 

  10. Kumamoto K, Nakamura T, Suzuki T, Gorai I, Fujinawa O, Ohta H, Shiraki M, Yoh K, Fujiwara S, Endo N, Matsumoto T (2010) Validation of the Japanese Osteoporosis Quality of Life Questionnaire. J Bone Miner Metab 28:1–7

    Article  PubMed  Google Scholar 

  11. Kuroda T, Shiraki M, Tanaka S, Ohta H (2009) Contributions of 25-hydroxyvitamin D, co-morbidities and bone mass to mortality in Japanese postmenopausal women. Bone 44:168–172

    Article  PubMed  CAS  Google Scholar 

  12. Roth HJ, Zahn I, Alkier R, Schmidt H (2001) Validation of the first automated chemiluminescence protein-binding assay for the detection of 25-hydroxycalciferol. Clin Lab 47:365–367

    Google Scholar 

  13. Murakami K, Sasaki S, Takahashi Y, Okubo H, Hirota N, Notsu A, Fukui M, Date C (2008) Reproducibility and relative validity of dietary glycaemic index and load assessed with a self-administered diet-history questionnaire in Japanese adults. Br J Nutr 99:639–648

    Article  PubMed  CAS  Google Scholar 

  14. Dietary Reference Intakes (2015). http://www.mhlw.go.jp/file/06-Seisakujouhou-10900000-Kenkoukyoku/Overview.pdf. Accessed 5 Oct 2017 (in English)

  15. Okazaki R, Ozono K, Fukumoto S, Inoue D, Yamauchi M, Minagawa M, Michigami T, Takeuchi Y, Matsumoto T, Sugimoto T (2017) Assessment criteria for vitamin D deficiency/insufficiency in Japan: proposal by an expert panel supported by the Research Program of Intractable Diseases, Ministry of Health, Labour and Welfare, Japan, the Japanese Society for Bone and Mineral Research and the Japan Endocrine Society (Opinion). J Bone Miner Metab 35:1–5

    Article  PubMed  CAS  Google Scholar 

  16. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J, IOF Committee of Scientific Advisors (CSA) Nutrition Working Group (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807–1820

    Article  PubMed  CAS  Google Scholar 

  17. Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, Pierroz DD, Weber P, Hoffmann K (2014) A systematic review of vitamin D status in populations worldwide. Br J Nutr 111:23–45

    Article  PubMed  CAS  Google Scholar 

  18. Kuchuk NO, Pluijm SM, van Schoor NM, Looman CW, Smit JH, Lips PJ (2009) Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons. J Clin Endocrinol Metab 94:1244–1250

    Article  PubMed  CAS  Google Scholar 

  19. Bischoff-Ferrari HA, Kiel DP, Dawson-Hughes B, Orav JE, Li R, Spiegelman D, Dietrich T, Willett WC (2009) Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. J Bone Miner Res 24:935–942

    Article  PubMed  CAS  Google Scholar 

  20. Yoshimura N, Muraki S, Oka H, Morita M, Yamada H, Tanaka S, Kawaguchi H, Nakamura K, Akune T (2013) Profiles of vitamin D insufficiency and deficiency in Japanese men and women: association with biological, environmental, and nutritional factors and coexisting disorders: the ROAD study. Osteoporos Int 24:2775–2787

    Article  PubMed  CAS  Google Scholar 

  21. Tamaki J, Iki M, Sato Y, Kajita E, Nishino H, Akiba T, Matsumoto T, Kagamimori S, For the JPOS Study Group (2017) Total 25-hydroxyvitamin D levels predict fracture risk: results from the 15-year follow-up of the Japanese Population-Based Osteoporosis (JPOS) Cohort Study. Osteoporos Int 28:1903–1913

    Article  PubMed  CAS  Google Scholar 

  22. Nakamura K, Nashimoto M, Tsuchiya Y, Obata A, Miyanishi K, Yamamoto M (2001) Vitamin D insufficiency in Japanese female college students: a preliminary report. Int J Vitam Nutr Res 71:302–305

    Article  PubMed  CAS  Google Scholar 

  23. Guidelines for Prevention and Treatment of Osteoporosis (2015). http://jsbmr.umin.jp/pdf/GL2015.pdf. Accessed 5 Oct 2017 (in Japanese)

  24. Choi SW, Kweon SS, Choi JS, Rhee JA, Lee YH, Nam HS, Jeong SK, Park KS, Ryu SY, Song HR, Shin MH (2016) The association between vitamin D and parathyroid hormone and bone mineral density: the Dong-gu Study. J Bone Miner Metab 34:555–563

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to express their sincere acknowledgement to the people who voluntarily participated in the present study. This study was financially supported by a grant from the Japan Osteoporosis Foundation.

Author information

Authors and Affiliations

  1. Clinical Medical Research Center, International University of Health and Welfare, Women’s Medical Center, Sanno Medical Center, 8-5-35 Akasaka, Minato-ku, Tokyo, 107-0052, Japan

    Hiroaki Ohta

  2. Public Health Research Foundation, 1-1-7 Nishiwaseda, Shinjuku-ku, Tokyo, 169-0051, Japan

    Tatsuhiko Kuroda

  3. Laboratory of Public Health, Department of Health and Nutrition, Osaka Shoin Women’s University, 4-2-26 Hishiyanishi, Higashi-Osaka, Osaka, 577-8550, Japan

    Naoko Tsugawa

  4. Department of Obstetrics and Gynecology, Tokyo Women’s Medical University Hospital, 8-1 Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Yoshiko Onoe

  5. Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan

    Toshio Okano

  6. Department of Internal Medicine, Research Institute and Practice for Involutional Diseases, 1610-1 Meisei, Misato, Azumino, Nagano, 399-8101, Japan

    Masataka Shiraki

Authors
  1. Hiroaki Ohta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tatsuhiko Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Naoko Tsugawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshiko Onoe
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Toshio Okano
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masataka Shiraki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hiroaki Ohta.

Ethics declarations

Conflict of interest

H.O. received lecture fees from Pfizer. M.S. received consulting fees from Asahi Kasei Pharma and Teijin Pharma. T.K. is an employee of Asahi Kasei Corporation. N.T., Y.O., and T.O. have no conflicts of interest.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ohta, H., Kuroda, T., Tsugawa, N. et al. Optimal vitamin D intake for preventing serum 25-hydroxyvitamin D insufficiency in young Japanese women. J Bone Miner Metab 36, 620–625 (2018). https://doi.org/10.1007/s00774-017-0879-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00774-017-0879-7

Keywords

Search

Navigation