Journal of Bone and Mineral Metabolism

, Volume 36, Issue 5, pp 609–619 | Cite as

Positive association between serum uric acid and bone mineral density in Chinese type 2 diabetes mellitus stratified by gender and BMI

  • Mingxin Xu
  • Junlei Su
  • Jie Hao
  • Ni Zhong
  • Zhiyin Zhang
  • Ran Cui
  • Feng Li
  • Chunjun Sheng
  • Ge Zhang
  • Hui ShengEmail author
  • Shen Qu
Original Article


Accumulating evidence has demonstrated that serum uric acid (UA), a natural powerful antioxidant, plays a beneficial role in bone health in the general population. However, few reports are available on the association between serum UA and bone in patients with type 2 diabetes mellitus (T2DM). We therefore investigated whether the benefit of serum UA for bone health was still present in those patients. 626 males and 609 postmenopausal females with T2DM were enrolled in this cross-sectional study. Serum UA concentrations and bone mineral density (BMD) measured at lumbar spine, femoral neck and total hip by dual-energy X-ray absorptiometry were obtained from all subjects. Meanwhile, data on osteoporosis prevalence, glucose metabolism, bone turnover markers and other serum biochemical indexes were collected. After adjustment for potential confounders, the results suggested that serum UA was positively associated with BMD in patients with normal weight, but this positive association varied by gender and skeletal sites in overweight T2DM patients [body mass index (BMI) ≥ 25 kg/m2]. Moreover, significantly lower odds ratios (ORs) for osteoporosis were found in postmenopausal patients with the highest UA tertile and male patients with medium UA tertile [adjusted OR 0.315, 95% confidence interval (CI) 0.170–0.581 for postmenopausal patients; adjusted OR 0.464, 95% CI 0.225–0.955 for male patients]. The positive association between serum UA and BMD found in Chinese T2DM patients may imply that relatively high UA is a protective factor for bone in these patients. Large intervention studies are needed to further confirm the outcomes and provide possible explanations.


Uric acid Type 2 diabetes mellitus Bone mineral density Osteoporosis BMI 



This study was supported by Shanghai Municipal Natural Science Foundation (13ZR1432100), National High Technology Research and Development Program (2013AA032203) and National Natural Science Foundation of China (NSFC 81500650).

Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no competing interests.

Supplementary material

774_2017_877_MOESM1_ESM.docx (38 kb)
Supplementary material 1 (DOCX 38 kb)


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan KK 2017

Authors and Affiliations

  • Mingxin Xu
    • 1
  • Junlei Su
    • 1
  • Jie Hao
    • 1
  • Ni Zhong
    • 1
  • Zhiyin Zhang
    • 1
  • Ran Cui
    • 1
  • Feng Li
    • 1
  • Chunjun Sheng
    • 1
  • Ge Zhang
    • 2
  • Hui Sheng
    • 1
    Email author
  • Shen Qu
    • 1
  1. 1.Department of Endocrinology and MetabolismShanghai Tenth People’s Hospital, Tongji University School of MedicineShanghaiChina
  2. 2.Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese MedicineHong Kong Baptist UniversityKowloon TongHong Kong

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