Journal of Bone and Mineral Metabolism

, Volume 36, Issue 4, pp 478–487 | Cite as

Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis

  • Kosuke EbinaEmail author
  • Makoto Hirao
  • Jun Hashimoto
  • Keisuke Hagihara
  • Masafumi Kashii
  • Kazuma Kitaguchi
  • Hozo Matsuoka
  • Toru Iwahashi
  • Ryota Chijimatsu
  • Hideki Yoshikawa
Original Article


The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics of the 194 female patients included in the study were 183 postmenopausal, age 65.9 years, lumbar spine (LS) T score −1.8, femoral neck (FN) T score −2.3, dose and rate of taking oral prednisolone (3.6 mg/day) 75.8%, and prior BP treatment duration 40.0 months. The patients were allocated to (1) the BP-continue group (n = 80), (2) the switch-to-DMAb group (n = 74), or (3) the switch-to-TPTD group (n = 40). After 18 months, the increase in bone mineral density (BMD) was significantly greater in the switch-to-DMAb group than in the BP-continue group (LS 5.2 vs 2.3%, P < 0.01; FN 3.8 vs 0.0%, P < 0.01) and in the switch-to-TPTD group than in the BP-continue group (LS 9.0 vs 2.3%, P < 0.001; FN 4.9 vs 0.0%, P < 0.01). Moreover, the switch-to-TPTD group showed a higher LS BMD (P < 0.05) and trabecular bone score (TBS) (2.1 vs −0.7%; P < 0.05) increase than the switch-to-DMAb group. Clinical fracture incidence during this period was 8.8% in the BP-continue group, 4.1% in the switch-to-DMAb group, and 2.5% in the switch-to-TPTD group. Both the switch-to-DMAb group and the switch-to-TPTD group showed significant increases in LS and FN BMD, and the switch-to-TPTD group showed a higher increase in TBS compared to the BP-continue group at 18 months. Switching BPs to DMAb or TPTD in female RA may provide some useful osteoporosis treatment options.


Bisphosphonate Denosumab Osteoporosis Rheumatoid arthritis Teriparatide 



The authors would like to thank Dr. Masao Yukioka and Dr. Kenrin Shi for their excellent cooperation in conducting the study.

Compliance with ethical standards

Conflict of interest

K. Ebina, M. Hirao, J. Hashimoto, and H. Yoshikawa have received research grants from Astellas Pharma and Eisai Co. Ltd. K. Ebina, M. Hirao, K. Hagihara, and H. Yoshikawa have received research grants from Daiichi Sankyo. H. Yoshikawa has received a research grant from MSD. K. Hagihara has received a research grant from Eli Lily. K. Ebina has received payments for lectures from Daiichi Sankyo. M. Kashii, K. Kitaguchi, H. Matsuoka, T. Iwahashi, R. Chijimatsu declare that they have no conflicts of interest. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan KK 2017

Authors and Affiliations

  • Kosuke Ebina
    • 1
    Email author
  • Makoto Hirao
    • 1
  • Jun Hashimoto
    • 2
  • Keisuke Hagihara
    • 3
  • Masafumi Kashii
    • 4
  • Kazuma Kitaguchi
    • 1
  • Hozo Matsuoka
    • 1
  • Toru Iwahashi
    • 1
  • Ryota Chijimatsu
    • 1
  • Hideki Yoshikawa
    • 1
  1. 1.Department of Orthopaedic Surgery, Graduate School of MedicineOsaka UniversitySuitaJapan
  2. 2.Department of RheumatologyNational Hospital Organization, Osaka Minami Medical CenterKawachinaganoJapan
  3. 3.Department of Kampo Medicine, Graduate School of MedicineOsaka UniversitySuitaJapan
  4. 4.Department of Orthopaedic SurgeryToyonaka Municipal HospitalToyonakaJapan

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