Journal of Bone and Mineral Metabolism

, Volume 34, Issue 4, pp 422–428 | Cite as

Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study

  • Mohammad Reza Kalantarhormozi
  • Majid Assadi
  • Katayoun Vahdat
  • Kamyar Asadipooya
  • Afshin Ostovar
  • Katayoun Raissi
  • Hossein Darabi
  • Shokrollah Farrokhi
  • Sina Dobaradaran
  • Maryam Farrokhnia
  • Iraj NabipourEmail author
Original Article


The potential link between infection with Chlamydia pneumoniae or Helicobacter pylori and osteoporosis has not been investigated in population-based longitudinal studies. A total of 250 healthy postmenopausal women who participated in a prospective cohort study were evaluated for IgG antibodies directed against C. pneumoniae and H. p ylori, osteoprotegerin (OPG), the receptor activator of nuclear factor kappa B ligand (RANKL), CrossLaps, and osteocalcin. Bone mineral density (BMD) was measured at the femoral neck and lumbar spine at baseline and at follow-up 5.8 years later. There were no significant differences in age-adjusted bone turnover markers, OPG, RANKL, the RANKL/OPG ratio, and BMD between the C. p neumoniae and H. p ylori IgG seropositive and seronegative subjects (P > 0.05). Neither C. p neumoniae nor H. p ylori IgG seropositivity was associated with age-and body mass index-adjusted BMD at the femoral neck and lumbar spine or bone loss at the 5.8-year follow-up. In logistic regression analysis, neither C. p neumoniae nor H. p ylori IgG seropositivities predicted incident lumbar or spine osteoporosis 5.8 years later. In conclusion, neither C. p neumoniae nor H. p ylori IgG seropositivity was associated with bone turnover markers, the RANKL/OPG ratio, BMD, or bone loss in postmenopausal women. In addition, chronic infection with C. p neumoniae or H. p ylori did not predict incident osteoporosis among this group of women.


Chlamydia pneumoniae Helicobacter pylori Bone mineral density Osteoporosis 



This project was supported jointly by a grant from Bushehr University of Medical Sciences and Health Services; the Ministry of Health; Tehran Endocrine Research Center; Tehran University of Medical Science, Tehran, Islamic Republic of Iran; and Bushehr Province Research Committee (PGHRC: 1385.234.345). The authors thank Dr. Syed Reza Imami, Shiva Mosadeghzadeh, and Zahra Amiri for assistance in the field work.

Conflict of interest

An award was given to Iraj Nabipour by “Novo Nordisk Pars” (The Best Innovator of Diabetes in Iran 2013). All other authors have no conflicts of interest.


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan 2015

Authors and Affiliations

  • Mohammad Reza Kalantarhormozi
    • 1
  • Majid Assadi
    • 2
  • Katayoun Vahdat
    • 3
  • Kamyar Asadipooya
    • 4
  • Afshin Ostovar
    • 3
  • Katayoun Raissi
    • 1
  • Hossein Darabi
    • 3
  • Shokrollah Farrokhi
    • 3
  • Sina Dobaradaran
    • 3
  • Maryam Farrokhnia
    • 5
  • Iraj Nabipour
    • 5
    • 6
    Email author
  1. 1.Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research CentreBushehr University of Medical SciencesBushehrIran
  2. 2.The Persian Gulf Nuclear Medicine Research CentreBushehr University of Medical SciencesBushehrIran
  3. 3.Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research CentreBushehr University of Medical SciencesBushehrIran
  4. 4.Division of Endocrinology and MetabolismUniversity of Kansas Medical CenterKansas CityUSA
  5. 5.Department of Biochemistry, The Persian Gulf Marine Biotechnology Research CentreBushehr University of Medical SciencesBushehrIran
  6. 6.The Persian Gulf Tropical Medicine Research CenterBushehrIran

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