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Journal of Bone and Mineral Metabolism

, Volume 32, Issue 4, pp 400–404 | Cite as

Relationships between serum adipocyte hormones (adiponectin, leptin, resistin), bone mineral density and bone metabolic markers in osteoporosis patients

  • J. Mohiti-ArdekaniEmail author
  • H. Soleymani-Salehabadi
  • M. B. Owlia
  • A. Mohiti
Original Article

Abstract

The purpose of this study was to investigate the relationship between fasting serum leptin, adiponectin and resistin levels and bone mineral density (BMD) in osteoporosis patients and a non-osteoporosis control group. We studied 81 non-diabetic osteoporosis patients (92 % female, 8 % male; mean age 54.5 ± 15.5 years and body mass index [BMI] 28.2 ± 4.6) and 120 non-diabetic individuals with normal BMD as controls (86 % female, 14 % male; mean age 39.7 ± 10.4 years and BMI 28.8 ± 4.4). BMD was studied by dual-energy X-ray absorptiometry from the lumbar spine (L1–L4) and femoral neck and fasting blood samples were taken for biochemical measurement of fasting blood glucose, leptin, adiponectin and resistin. Fasting levels of plasma adiponectin had a significant negative correlation with BMD of the femoral neck and lumbar spine in the osteoporosis group (r = −0.478, P = 0.003, r = −0.513, P = 0.023) but not in the non-osteoporosis group (r = −0.158, P = 0.057, r = −0.23, P = 0.465). Fasting plasma levels of resistin were significantly correlated only with femur BMD in the osteoporosis group, and not significantly correlated with lumbar spine BMD (r = −0.244, P = 0.048 vs r = 0.276, P = 0.56). Leptin did not have a significant correlation with BMD in either the osteoporosis or non-osteoporosis groups (P > 0.05). Adiponectin had a significant negative correlation with BMD of the lumbar spine and femoral neck. The correlation between leptin and resistin are not inconclusive.

Keywords

Osteoporosis BMD Adiponectin Leptin Resistin 

Notes

Acknowledgments

This study was supported by Shahid Sadoughi University of Medical Sciences. We greatly acknowledge Research Deputy of Shahid Sadoughi University of Medical Sciences for supporting the present project.

Conflict of interest

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

References

  1. 1.
    Lim S, Joung H, Shin CS, Lee HK, Kim KS, Shin EK, Kim HY, Lim MK, Cho SI (2004) Body composition changes with age have gender-specific impacts on bone mineral density. Bone 35:792–798PubMedCrossRefGoogle Scholar
  2. 2.
    Felson DT, Zhang Y, Hannan MT, Anderson J (1993) Effects of weight and body mass index on bone mineral density in men and women. J Bone Miner Res 8:567–573PubMedCrossRefGoogle Scholar
  3. 3.
    Glauber HS, Vollmer WM, Nevitt MC, Ensrud KE, Orwoll ES (1995) Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density. J Clin Endocrinol Metab 80:1118–1123PubMedGoogle Scholar
  4. 4.
    Lenchik L, Register TC, Lohman K, Hsu F-C, Nicklas BJ, Freedman BI, Langefeld CD, Carr JJ, Bowden DW (2003) Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone 33:646–651PubMedCrossRefGoogle Scholar
  5. 5.
    won Muhlen D, Safii S, Jassal SK, Svartberg J, Barrett-Connor E (2007) Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study. Osteoporos Int 18:1337–1344CrossRefGoogle Scholar
  6. 6.
    Maeda K, Okubo K, Shimomura I, Mizuno K, Matsuzawa Y, Matsubara K (1997) Analysis of an expression profile of genes in the human adipose tissue. Gene 190:227–235PubMedCrossRefGoogle Scholar
  7. 7.
    Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura Nakamura T et al (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79–83PubMedCrossRefGoogle Scholar
  8. 8.
    Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L (2001) Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest 108:1875–1881PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947–953PubMedCrossRefGoogle Scholar
  10. 10.
    Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Yamamoto M, Sugimoto T (2007) Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells. BMC Cell Biol 8:51–62PubMedCentralPubMedCrossRefGoogle Scholar
  11. 11.
    Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE (2004) Adiponectin and its receptors are expressed in bone-forming cells. Bone 35:842–849PubMedCrossRefGoogle Scholar
  12. 12.
    Williams GA, Wang Y, Callon KE, Watson M, Lam JB, Lin JM, Janice BB, Costa JL, Orpe A, Broom N, Naot D, Reid IR, Cornish J (2009) In vitro and in vivo effects of adiponectin on bone. Endocrinology 150:3603–3610PubMedCrossRefGoogle Scholar
  13. 13.
    Brennan AM, Mantzoros CS (2006) Drug insight: the role of leptin in human physiology and pathophysiology-emerging clinica applications. Nat Rev Endocrinol 2:318–327Google Scholar
  14. 14.
    Thomas T, Burguera B, Melton LJ, Atkinson E, Riggs BL, Khosla S (2004) Relationship of serum leptin levels with body composition, sex steroid, and insulin levels in women and men. Metabolism 9:1278–1284Google Scholar
  15. 15.
    Burguera B, Hofbau L, Thomas L, Gori F, Lamsam J et al (2001) Leptin reduces ovariectomy-induced bone loss. Endocrinology 142:3546–3553PubMedCrossRefGoogle Scholar
  16. 16.
    Ducy P, Amling M, Takeda S, Priemel M, Schilling AF et al (2000) Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100:197–207PubMedCrossRefGoogle Scholar
  17. 17.
    Jürimäe J, Jürimäe T, Leppik A, Kums T (2008) The influence of ghrelin, adiponectin, and leptin on bone mineral density in healthy postmenopausal women. J Bone Miner Metab 26:618–623PubMedCrossRefGoogle Scholar
  18. 18.
    OdabaI E, Ozata M, Turan M, Bingo N, Yonem A, Cakir B, Kutlu M, Ozdemir IC (2000) Plasma leptin concentrations in postmenopausal women with osteoporosis. Eur J Endocrinol 142:170–173CrossRefGoogle Scholar
  19. 19.
    Gonnelli S, Caffarelli C, Del Santo K, Cadirni A, Guerriero C, Lucani B, Franci B, Nuti R (2008) The relationship of ghrelin and adiponectin with bone mineral density and bone turnover markers in elderly men. Calcif Tissue Int 83:55–60PubMedCrossRefGoogle Scholar
  20. 20.
    Ozkurt B, Ozkurt ZN, Altay M, Aktekin CN, Caðlayan O, Tabak Y (2009) The relationship between serum adiponectin level and anthropometry bone mass osteoporotic fracture skin postmeno-pausal women. Eklem Hastalik Cerrahisi 20:78–84PubMedGoogle Scholar
  21. 21.
    Canhao H, Fonseca JE, Caetano-Lopes J, Saldanha C, Queiroz MV (2008) Assessment of laboratory measurements and -308 TNF gene promoter polymorphisms in normal bone mineral density. Clin Rheumatol 27:301–307PubMedCrossRefGoogle Scholar
  22. 22.
    Kontogianni MD, Dafni UG, Routsias G, Skopouli FN (2004) Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Miner Res 19:546–551PubMedCrossRefGoogle Scholar
  23. 23.
    Pang XD, Xian H, Zhao Q, Wu XP, Sun ZQ, Liao EY (2008) Relationships between serum adiponectin, leptin, resistin, visfatin levels and bone mineral density, and bone biochemical markers in Chinese men. Clin Chim Acta 387:31–35CrossRefGoogle Scholar
  24. 24.
    Jürimäe J, Jürimäe T (2007) Adiponectin is a predictor of bone mineral density in middle-aged premenopausal women. Osteoporos Int 18:1253–1259PubMedCrossRefGoogle Scholar
  25. 25.
    Jurima J, Rembel K, Jurimae T, Rehand M (2005) Adiponectin is associated with bone mineral density in perimenopausal women. Horm Metab Res 37:297–302CrossRefGoogle Scholar
  26. 26.
    Ealey KN, Kaludjerovic J, Archer MC, Ward WE (2008) Adiponectin is a negative regulator of bone mineral and bone strength in growing mice. Exp Biol Med (Maywood) 233:1546–1553CrossRefGoogle Scholar
  27. 27.
    Richards JB, Valdes AM, Burling K, Perks UC, Spector TD (2007) Serum adiponectin and bone mineral density in women. ICEM 92:1517–1523Google Scholar
  28. 28.
    Sato M, Takeda N, Sarui H, Takami R, Takami K, Hayashi M et al (2001) Association between serum leptin concentrations and bone mineral density, and biochemical markers of bone turnover in adult men. JCEM 86:5273–5276PubMedGoogle Scholar
  29. 29.
    Zhong N, Wu XP, Xu ZR, Wang AH, Luo XH, Cao XZ, Xie H, Shan PF, Liao EY (2005) Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta 351:161–168PubMedCrossRefGoogle Scholar
  30. 30.
    Parm AL, Jürimäe J, Saar M, Pärna K, Tillmann V, Maasalu K, Neissaar I, Jürimäe T (2011) Plasma adipocytokine and ghrelin levels in relation to bone mineral density in prepubertal rhythmic gymnasts. J Bone Miner Metab 9:717–724CrossRefGoogle Scholar
  31. 31.
    Tamura T, Yoneda M, Yamane K, Nakanishi S, Nakashima R, Okubo M, Kohno N (2007) Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus. Metabolism 56:623–628PubMedCrossRefGoogle Scholar
  32. 32.
    Oshima K, Nampei AM, Iwaki M, Fukuhara A, Hashimoto J, Yoshikawa H, Shimomura I (2005) Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 331:520–526PubMedCrossRefGoogle Scholar
  33. 33.
    Luo XH, Guo LJ, Xie H, Yuan LQ, Wu XP, Zhou HD, Liao EY (2006) Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res 21:1648–1656PubMedCrossRefGoogle Scholar
  34. 34.
    Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, Depinho RA, Guo EX, Mann JJ, Karsenty G (2013) Adiponectin regulates bone mass via opposite central and peripheral mechanism through FoxO1. Cell Metab 17:901–915PubMedCentralPubMedCrossRefGoogle Scholar
  35. 35.
    Shinoda Y, Yamaguchi M, Ogata N (2006) Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 99:196–208PubMedCrossRefGoogle Scholar
  36. 36.
    Atalay A, Elic H, Kayadibi N, Nurettin A (2012) Diagnostic utility of osteocalcin, under carboxylated osteocalcin and alkaline phosphatase for osteoporosis in premenopausal and postmenopausal women. Ann Lab Med 32:23–30PubMedCentralPubMedCrossRefGoogle Scholar
  37. 37.
    Ochoa S, Arantazu F, Diego R, Rebeca M, Raya M, Manuel M (2012) Adiponectin and leptin serum levels in osteoporotic postmenopausal women treated with reloxifene or alendronate. Menopause 19:172–177CrossRefGoogle Scholar
  38. 38.
    Biver E, Salliot C, Combescure C, Gossec L, Hardouin P, Legroux-Gerot I, Cortet B (2011) Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis. J Clin Endocrinol Metab 21:56–61Google Scholar
  39. 39.
    Chanprasertyothin S, Piaseu N, Chailurkit L, Rajatanavin R, Ongphiphadhanakul B (2005) Association of circulating leptin with bone mineral density in males and females. J Med Assoc Thai 88:655–659PubMedGoogle Scholar
  40. 40.
    Martini G, Valenti R, Giovani S, Franci B, Campagna S, Nuti R (2001) Influence of insulin- like growth factor-1 and leptin on bone mass in healthy postmenopausal women. Bone 28:113–117PubMedCrossRefGoogle Scholar
  41. 41.
    Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T et al (2002) Genetic variation in the gene encoding adiponectin in associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51:536–540PubMedCrossRefGoogle Scholar

Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan 2013

Authors and Affiliations

  • J. Mohiti-Ardekani
    • 1
    Email author
  • H. Soleymani-Salehabadi
    • 2
  • M. B. Owlia
    • 2
  • A. Mohiti
    • 3
  1. 1.Department of Biochemistry and Molecular Biology, Faculty of MedicineShahid Saduoghi University of Medical ScienceYazdIran
  2. 2.Department of Rheumatology, Faculty of MedicineShahid Saduoghi University of Medical ScienceYazdIran
  3. 3.Faculty of MedicineShahid Saduoghi University of Medical ScienceYazdIran

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