Journal of Bone and Mineral Metabolism

, Volume 31, Issue 1, pp 1–15 | Cite as

Guidelines for the use of bone metabolic markers in the diagnosis and treatment of osteoporosis (2012 edition)

  • Yoshiki NishizawaEmail author
  • Hiroaki Ohta
  • Masakazu Miura
  • Masaaki Inaba
  • Schoichi Ichimura
  • Masataka Shiraki
  • Junichi Takada
  • Osamu Chaki
  • Hiroshi Hagino
  • Saeko Fujiwara
  • Masao Fukunaga
  • Takami Miki
  • Noriko Yoshimura
Special Report


Recently the clinical application of bone metabolic markers has achieved significant progress and the measurements of these indices give us a better understanding of the pathogenesis of osteoporosis. Bone metabolic markers were adapted to select drug treatment for osteoporosis and to evaluate drug efficacy. Therefore, the proper application and assessment of bone metabolic markers in clinical practice is very important. To achieve these aims, the committee on the guidelines for the use of biochemical markers of bone turnover in osteoporosis authorized by the Japan Osteoporosis Society has summarized recent progress in bone markers and proposed the proper utilization of bone markers. Although the use of bone metabolic markers now has an important role in the daily management of osteoporosis, their use in Japan is still insufficient because of insurance coverage limitations. Since the Japan Osteoporosis Society first created the 2001 guidelines, new bone metabolic markers have been introduced into clinical practice. The availability of new osteoporosis treatments that promote bone formation has changed the clinical application of bone metabolic markers in current practice. Therefore, revisions to the current clinical practice are needed which led to the proposal to create these new 2012 guidelines.


Guideline Bone metabolic marker Osteoporosis 


Conflict of interest

All authors declare that they have no conflict of interest.


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan 2012

Authors and Affiliations

  • Yoshiki Nishizawa
    • 1
    Email author
  • Hiroaki Ohta
    • 2
  • Masakazu Miura
    • 3
  • Masaaki Inaba
    • 4
  • Schoichi Ichimura
    • 5
  • Masataka Shiraki
    • 6
  • Junichi Takada
    • 7
  • Osamu Chaki
    • 8
  • Hiroshi Hagino
    • 9
  • Saeko Fujiwara
    • 10
  • Masao Fukunaga
    • 11
  • Takami Miki
    • 12
  • Noriko Yoshimura
    • 13
  1. 1.Osaka City UniversityOsakaJapan
  2. 2.Clinical Medical Research CenterInternational University of Health and Welfare, Women’s Medical Center, Sanno Medical CenterTokyoJapan
  3. 3.Department of Pharmaceutical SciencesHokuriku UniversityKanazawaJapan
  4. 4.Department of Metabolism, Endocrinology and Molecular MedicineOsaka City University Graduate School of MedicineOsakaJapan
  5. 5.Department of Orthopaedic SurgeryKyorin University School of MedicineMitakaJapan
  6. 6.Department of Internal MedicineResearch Institute and Practice for Involutional DiseasesNaganoJapan
  7. 7.Department of Orthopaedic SurgerySapporo Medical UniversitySapporoJapan
  8. 8.Obstetrics and GynecologyYokohama Rosai HospitalYokohamaJapan
  9. 9.School of Health ScienceTottori University Faculty of MedicineYonagoJapan
  10. 10.Health Management and Promotion CenterHiroshima Atomic Bomb Casualty CouncilHiroshimaJapan
  11. 11.Kawasaki Medical SchoolKurashikiJapan
  12. 12.Department of Geriatric Medicine and NeurologyOsaka City University Graduate School of MedicineOsakaJapan
  13. 13.Department of Joint Disease Research, 22nd Century Medical and Center, Graduate School of MedicineThe University of TokyoTokyoJapan

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