Journal of Bone and Mineral Metabolism

, Volume 29, Issue 3, pp 321–327 | Cite as

Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease

  • Athanasios Christoforidis
  • Nikoleta Printza
  • Chrysa Gkogka
  • Ekaterini Siomou
  • Anna Challa
  • Eirini Kazantzidou
  • Konstantinos Kollios
  • Fotis Papachristou
Original Article


Our aim was to assess bone parameters in children with chronic kidney disease (CKD) with both dual-energy X-ray absorptiometry (DXA) and quantitative ultrasonography (QUS) and additionally with biochemical markers of bone turnover. Twenty children (12 boys and 8 girls) with CKD and a mean decimal age of 9.47 ± 4.44 years were included in the study where anthropometric parameters (height and weight), pubertal status, bone mineral density (BMD) at lumbar spine, speed of sound (SOS) measured by QUS at radius and at tibia, and biochemical markers of bone metabolism were measured. Six patients (30%) had tibial SOS Z score <−1, and 52.7% had radial SOS Z score <−1, whereas only 16.67% had BMD Z score <−1. Patients had significantly increased levels of serum intact parathormone (p < 0.001), serum bone alkaline phosphatase (BAP) (p < 0.001) and serum N-terminal-mid fragment (aminoacids 1-43) of osteocalcin (p < 0.001) compared to controls, whereas serum osteoprotegerin was significantly decreased in patients compared to controls (p = 0.001). SOS was significantly correlated to BAP (r = −0.586, p = 0.013 and r = −0.709, p = 0.001, respectively, for radius and tibia). In conclusion no association between DXA and QUS measurements was documented in our study, whereas QUS was better correlated to biochemical indices of ROD.


Renal osteodystrophy Chronic kidney disease Dual-energy X-ray absorptiometry Quantitative ultrasonography Children 


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer 2010

Authors and Affiliations

  • Athanasios Christoforidis
    • 1
  • Nikoleta Printza
    • 1
  • Chrysa Gkogka
    • 1
  • Ekaterini Siomou
    • 2
  • Anna Challa
    • 2
  • Eirini Kazantzidou
    • 3
  • Konstantinos Kollios
    • 4
  • Fotis Papachristou
    • 1
  1. 1.1st Paediatric DepartmentAristotle UniversityThessalonikiGreece
  2. 2.Department of Child Health, Medical SchoolUniversity of IoanninaIoanninaGreece
  3. 3.Radiology Department“Ippokratio” HospitalThessalonikiGreece
  4. 4.3rd Paediatric DepartmentAristotle UniversityThessalonikiGreece

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