Familial correlation of bone mineral density, birth data and lifestyle factors among adolescent daughters, mothers and grandmothers
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This study aimed to clarify the relationship between skeletal or lifestyle factors among Japanese daughter-mother, mother-grandmother and daughter-grandmother pairs. We performed a cross-sectional study in a cohort of Japanese adolescent daughters (12–18 years of age), their mothers (339 pairs) and grandmothers on their mothers’ side (34 pairs). Gestational age, birth weight, age at menarche and presence of menarche or menopause were surveyed in the participants. Height, body weight and lumbar 2–4 bone mineral density (BMD) were measured. Dietary intake and current physical activity were assessed by using questionnaires. Gestational age and age at menarche were significantly correlated among daughters, mothers and grandmothers (P < 0.001). BMD was significantly correlated between daughters and mothers (P < 0.001), while it was not significantly correlated between daughters and grandmothers or between mothers and grandmothers. Dietary intake of calcium and vitamin D, and the frequency, duration and intensity of current physical activity were significantly correlated between daughters and mothers (P < 0.05), although no significant correlation was found between daughters and grandmothers, or between mothers and grandmothers. The parameters for exercise indicated a positive correlation for BMD in the daughters and the mothers, but not in the grandmothers. The results suggested that estrogen deficiency decreases familial correlation for BMD after menopause. Achieving high BMD through exercise may be important for prevention of postmenopausal osteoporosis in premenopausal low-height mothers.
KeywordsBone mineral density Lifestyle Familial correlation Estrogen deficiency
This work was partly supported by a grant-in-aid from the Japan Osteoporosis Foundation.
- 5.Silverman SL, Minshall ME, Shen W, Harper KD, Xie S (2001) The relationship of health-related quality of life to prevalent and incident vertebral fractures in postmenopausal women with osteoporosis: results from the Multiple Outcomes of Raloxifene Evaluation Study. Arthritis Rheum 44:2611–2619CrossRefPubMedGoogle Scholar
- 17.Science and Technology Agency (2000) Standard tables of food composition in Japan, 5th edn. Printing Bureau, Ministry of Finance, Tokyo (in Japanese)Google Scholar
- 18.Orimo H, Sugioka H, Fukunaga M, Mutoh Y, Hotokebuchi T, Gorai I, Nakamura T, Kushida K, Tanaka H, Ikai T, Ohashi Y, Osteoporosis Diagnostic Criteria Review Committee: Japanese Society for Bone, Mineral Research (1997) Diagnostic criteria for primary osteoporosis: year 1996 revision. Nihon Kotsutaisya Gakkai Zasshi 14:219–233 (in Japanese)Google Scholar
- 24.Lloyd T, Rollings N, Andon MB, Demers LM, Eggli DF, Kieselhorst K, Kulin H, Landis JR, Martel JK, Orr G (1992) Determinants of bone density in young women. I. Relationships among pubertal development, total body bone mass, and total body bone density in premenarchal females. J Clin Endocrinol Metab 75:383–387CrossRefPubMedGoogle Scholar
- 28.Going S, Lohman T, Houtkooper L, Metcalfe L, Flint-Wagner H, Blew R, Stanford V, Cussler E, Martin J, Teixeira P, Harris M, Milliken L, Figueroa-Galvez A, Weber J (2003) Effects of exercise on bone mineral density in calcium-replete postmenopausal women with and without hormone replacement therapy. Osteoporos Int 14:637–643CrossRefPubMedGoogle Scholar