Journal of Bone and Mineral Metabolism

, Volume 28, Issue 5, pp 591–594

Mediastinal parathyroid carcinoma presenting with severe skeletal manifestations

Case Report


Parathyroid carcinoma is a rare malignancy, accounting for about 1% of primary hyperparathyroidism. We report the case of a 23-year-old man who presented with poorly united mid-shaft fracture of the left femur with severe hypercalcaemia in the setting of 99 mTc sestamibi-avid lesions in the mediastinal and thoracic vertebrae. The patient underwent surgery, and histopathology revealed a low-grade parathyroid carcinoma. After surgery, the patient developed severe hungry bone syndrome requiring intensive calcium, magnesium and active vitamin D supplementation. A review of the literature was undertaken with regards to mediastinal parathyroid carcinoma, management of refractory hypercalcaemia in this setting and hungry bone syndrome.


Hyperparathyroidism Parathyroid carcinoma Hypercalcaemia Brown tumour 


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer 2010

Authors and Affiliations

  1. 1.Department of General Medicine, Flinders Medical Centre and School of MedicineFlinders UniversityBedford Park, AdelaideAustralia
  2. 2.Department of General MedicineFlinders Medical CentreBedford ParkAustralia

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