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Journal of Bone and Mineral Metabolism

, Volume 26, Issue 1, pp 73–78 | Cite as

Bone mineral density in prepubertal obese and control children: relation to body weight, lean mass, and fat mass

  • Emilie RocherEmail author
  • Christine Chappard
  • Christelle Jaffre
  • Claude-Laurent Benhamou
  • Daniel Courteix
ORIGINAL ARTICLE

Abstract

The aim of the study was to determine the influence of obesity on bone status in prepubertal children. This study included 20 obese prepubertal children (10.7 ± 1.2 years old) and 23 maturation-matched controls (10.9 ± 1.1 years old). Bone mineral area, bone mineral content (BMC), bone mineral density (BMD), and calculation of bone mineral apparent density (BMAD) at the whole body and lumbar spine (L1–L4) and body composition (lean mass and fat mass) were assessed by DXA. Broadband ultrasound attenuation (BUA) and speed of sound (SOS) at the calcaneus were measured with a BUA imaging device. Expressed as crude values, DXA measurements of BMD at all bone sites and BUA (69.30 versus 59.63 dB/MHz, P < 0.01) were higher in obese children. After adjustment for body weight and lean mass, obese children displayed lower values of whole-body BMD (0.88 versus 0.96 g/cm2, P < 0.05) and BMC (1190.98 versus 1510.24 g, P < 0.01) in comparison to controls. When results were adjusted for fat mass, there was no statistical difference between obese and control children for DXA and ultrasound results. Moreover, whole-body BMAD was lower (0.086 versus 0.099 g/cm3, P < 0.0001), whereas lumbar spine BMAD was greater (0.117 versus 0.100 g/cm3, P < 0.001) in obese children. Thus, it was observed that, in obese children, cortical and trabecular bone displayed different adaptation patterns to their higher body weight. Cortical bone seems to enhance both size and BMC and trabecular bone to enhance BMC. Finally, considering total body weight and lean mass of obese children, these skeletal responses were not sufficient to compensate for the excess load on the whole body.

Key words

children obesity body composition DXA QUS 

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Copyright information

© Springer-Verlag Tokyo 2008

Authors and Affiliations

  • Emilie Rocher
    • 1
    • 2
    Email author
  • Christine Chappard
    • 2
  • Christelle Jaffre
    • 1
  • Claude-Laurent Benhamou
    • 1
    • 2
  • Daniel Courteix
    • 1
  1. 1.Bone Tissue Architecture and Physical Exercise (ATOSEP Laboratory)University of OrleansFrance
  2. 2.Inserm U658Centre Hospitalier RégionalOrléansFrance

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