Journal of Bone and Mineral Metabolism

, Volume 24, Issue 4, pp 314–318

Effects of ospemifene and raloxifene on biochemical markers of bone turnover in postmenopausal women

  • Janne Komi
  • Kari S. Lankinen
  • Michael DeGregorio
  • Jorma Heikkinen
  • Seppo Saarikoski
  • Marjo Tuppurainen
  • Kaija Halonen
  • Risto Lammintausta
  • Kalervo Väänänen
  • Olavi Ylikorkala
  • Risto Erkkola
ORIGINAL ARTICLE

DOI: 10.1007/s00774-006-0689-9

Cite this article as:
Komi, J., Lankinen, K., DeGregorio, M. et al. J Bone Miner Metab (2006) 24: 314. doi:10.1007/s00774-006-0689-9

Abstract

Ospemifene is a novel selective estrogen receptor modulator (SERM) that is initially being developed for the treatment of vaginal atrophy in postmenopausal women. However, it also shows promise in the prevention and treatment of osteoporosis. As a part of a phase II trial, we compared the effects of ospemifene and raloxifene on bone turnover in postmenopausal women. The study was conducted as a randomized, double-blind study in which 118 healthy postmenopausal women received 30 (n = 29), 60 (n = 30), or 90 mg (n = 30) ospemifene or 60 mg (n = 29) raloxifene for 3 months. Bone resorption was assessed by measuring the urinary outputs of N- and C-terminal cross-linking telopeptides of type I collagen (NTX and CTX, respectively). Bone formation was assessed by measuring bone-specific alkaline phosphatase (bone ALP), osteocalcin (OC), procollagen type I N propeptide (PINP), and procollagen type I C propeptide (PICP) in serum. All markers were studied before and at 3 months and 2–4 weeks after cessation of the medication. Urine NTX outputs decreased in all study groups, and the only statistically significant difference in NTX was observed between raloxifene and 30 mg ospemifene, which was reduced more in the raloxifene group. The output of CTX decreased most clearly in 60- and 90-mg ospemifene groups, but no significant differences between study groups emerged. A significant difference was found between the 90-mg ospemifene group and raloxifene in PINP in favor of ospemifene. No other differences in bone formation markers emerged between ospemifene and raloxifene. The study confirms the bone-restoring activity of ospemifene, which is comparable to that of raloxifene.

Key words

ospemifene osteoporosis postmenopausal raloxifene SERM 

Copyright information

© Springer-Verlag Tokyo 2006

Authors and Affiliations

  • Janne Komi
    • 1
  • Kari S. Lankinen
    • 2
  • Michael DeGregorio
    • 3
  • Jorma Heikkinen
    • 4
  • Seppo Saarikoski
    • 5
  • Marjo Tuppurainen
    • 5
  • Kaija Halonen
    • 1
  • Risto Lammintausta
    • 1
  • Kalervo Väänänen
    • 6
  • Olavi Ylikorkala
    • 7
  • Risto Erkkola
    • 8
  1. 1.Hormos Medical CorporationTurkuFinland
  2. 2.PSR Consulting Ltd.HelsinkiFinland
  3. 3.Department of Internal Medicine, Division of Hematology and Oncology, Cancer CenterUniversity of California, DavisSacramentoUSA
  4. 4.Oulu Deaconess InstituteOuluFinland
  5. 5.Department of Obstetrics and GynecologyKuopio University HospitalKuopioFinland
  6. 6.Department of Anatomy, Institute of BiomedicineUniversity of TurkuTurkuFinland
  7. 7.Department of Obstetrics and GynecologyHelsinki University Central HospitalHelsinkiFinland
  8. 8.Department of Obstetrics and GynecologyTurku University Central HospitalTurkuFinland

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