Journal of Bone and Mineral Metabolism

, Volume 23, Issue 3, pp 226–230

Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5′-flanking region (−5229G/A) with bone mineral density

  • Tomohiko Urano
  • Masataka Shiraki
  • Masayo Fujita
  • Takayuki Hosoi
  • Hajime Orimo
  • Yasuyoshi Ouchi
  • Satoshi Inoue
ORIGINAL ARTICLE

Abstract

The 12/15-lipoxygenase gene Alox15 has been identified as a susceptibility gene for bone mineral density (BMD) in mice through combined genetic and genomic analyses. Here we studied the association between bone mineral density and an ALOX15 gene single nucleotide polymorphism to assess the potential involvement of the human ALOX15 gene in postmenopausal osteoporosis. Specifically, we examined the association between a single nucleotide polymorphism at −5299G/A in the ALOX15 5′-flanking region with BMD in 319 postmenopausal Japanese women (66.7 ± 8.9 years, mean ± SD). We found that subjects bearing at least one variant A allele (GA + AA; n = 273) had significantly lower Z scores for lumbar spine and total body bone mineral density than did subjects with no A allele (GG; n = 46) (lumbar spine, −0.25 ± 1.34 versus 0.48 ± 1.70; P = 0.0014; total body, 0.25 ± 1.01 vs 0.62 ± 1.11; P = 0.048). These findings suggest that the ALOX15 gene is one of the genetic determinants of BMD in postmenopausal women. Accordingly, this polymorphism could be useful as a genetic marker for predicting the risk of osteoporosis.

Key words

Adipogenesis ALOX15 PPARγ Osteoporosis Bone mineral density Polymorphism 

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Copyright information

© Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Tomohiko Urano
    • 1
  • Masataka Shiraki
    • 2
  • Masayo Fujita
    • 1
    • 3
  • Takayuki Hosoi
    • 4
  • Hajime Orimo
    • 5
  • Yasuyoshi Ouchi
    • 1
  • Satoshi Inoue
    • 1
    • 3
  1. 1.Department of Geriatric Medicine, Graduate School of MedicineUniversity of TokyoTokyoJapan
  2. 2.Research Institute and Practice for Involutional DiseasesNaganoJapan
  3. 3.Research Center for Genomic MedicineSaitama Medical SchoolSaitamaJapan
  4. 4.Tokyo Metropolitan Geriatric HospitalTokyoJapan
  5. 5.Health Science UniversityYamanashiJapan

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