Journal of Bone and Mineral Metabolism

, Volume 22, Issue 5, pp 479–485

Vitamin D receptor gene start codon polymorphism (FokI) is associated with forearm bone mineral density and calcaneal ultrasound in Finnish adolescent boys but not in girls

  • Marika M.L. Laaksonen
  • Merja U.M. Kärkkäinen
  • Terhi A. Outila
  • Hannu J. Rita
  • Christel J.E. Lamberg-Allardt
Article

DOI: 10.1007/s00774-004-0510-6

Cite this article as:
Laaksonen, M., Kärkkäinen, M., Outila, T. et al. J Bone Miner Metab (2004) 22: 479. doi:10.1007/s00774-004-0510-6

Abstract

We examined the association between vitamin D receptor (VDR) gene FokI polymorphism and bone mineral density and quantitative ultrasound parameters in Finnish adolescents. We assessed bone mineral density at the distal sites of radius and ulna, quantitative ultrasound of the calcaneus, serum concentration of 25-hydroxyvitamin D (25-OHD), calcium intake, physical activity, and BsmI and FokI polymorphisms of the vitamin D receptor gene in 86 girls and 38 boys aged 14 to 16 years. In girls, FokI polymorphism was not significantly associated with bone mineral density or quantitative ultrasound parameters. In adolescent boys, the Ff genotype was associated with higher forearm BMD and calcaneal ultrasound values, when adjusted for body and bone size, BsmI polymorphism, calcium intake, vitamin D status, smoking, and physical activity.

Key words

vitamin D receptor gene FokI polymorphism peak bone mass quantitative ultrasound 

Copyright information

© Springer-Verlag Tokyo 2004

Authors and Affiliations

  • Marika M.L. Laaksonen
    • 1
  • Merja U.M. Kärkkäinen
    • 1
  • Terhi A. Outila
    • 1
  • Hannu J. Rita
    • 2
  • Christel J.E. Lamberg-Allardt
    • 1
  1. 1.Calcium Research Unit, Department of Applied Chemistry and Microbiology, Division of NutritionUniversity of HelsinkiFinland
  2. 2.Integrative Ecology Unit, Department of Ecology and Systematics, Division of Population BiologyUniversity of HelsinkiFinland

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