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Accreditation and Quality Assurance

, Volume 14, Issue 2, pp 79–86 | Cite as

A new traceability scheme for the development of international system-traceable persistent organic pollutant reference materials by quantitative nuclear magnetic resonance

  • Takeshi SaitoEmail author
  • Toshihide Ihara
  • Masayoshi Koike
  • Shinichi Kinugasa
  • Yoshinori Fujimine
  • Kazutoshi Nose
  • Tetsuya Hirai
General Paper

Abstract

Quantitative nuclear magnetic resonance (qNMR) was used for the purity determination of neat compounds of persistent organic pollutants (POPs). qNMR is a unique quantitative method that is not only traceable to the International System of Units (SI), but it also does not require a standard of its own. The purities of the POP compounds determined in this work were traceable to a single certified reference material (CRM), which is extremely attractive for reference material producers. The purities observed by qNMR were equivalent to those observed by gas chromatography with flame ionization detection (GC/FID) or a differential scanning calorimetry (DSC) combined with a thermogravimetric analyzer (TGA). The uncertainties obtained by the qNMR method were comparable to being slightly larger than those observed by DSC.

Keywords

Quantitative NMR Purity determination Uncertainty Traceability POPs 

Notes

Acknowledgment

This work was supported by grants-in-aid from the Ministry of Economy, Trade and Industry, Japan.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Takeshi Saito
    • 1
    Email author
  • Toshihide Ihara
    • 1
  • Masayoshi Koike
    • 1
  • Shinichi Kinugasa
    • 1
  • Yoshinori Fujimine
    • 2
  • Kazutoshi Nose
    • 2
  • Tetsuya Hirai
    • 2
  1. 1.National Metrology Institute of Japan, AISTTsukubaJapan
  2. 2.Otuka Pharmaceutical Co., Ltd.TokushimaJapan

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