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Molekulare Charakterisierung des Pankreaskarzinoms

Therapeutische Implikationen
  • C. Benedikt WestphalenEmail author
  • Kathrin Heinrich
  • Stefan Böck
  • Volker Heinemann
Leitthema
  • 29 Downloads

Zusammenfassung

Hintergrund

Die Präzisionsonkologie erzielt mittlerweile große Erfolge in einer Vielzahl von malignen Erkrankungen. Basierend auf umfassender molekularer Charakterisierung konnte die Behandlungsrealität vieler Tumorerkrankungen entscheiden verändert, teils revolutioniert werden. Auch das Verständnis um die molekulare Pathologie des Bauchspeicheldrüsenkarzinoms hat in den vergangenen Jahren deutlich zugenommen. Ziel dieses Beitrags ist, mögliche präzisionsonkologische Ansätze in der Behandlung des Pankreaskarzinoms zu erläutern.

Schlussfolgerung

Das bessere Verständnis um die molekulare Pathologie des Pankreaskarzinoms hat aktuell noch keinen entscheidenden Einfluss auf dessen therapeutische Realität und hat sich dementsprechend noch nicht auf die weiterhin schlechte Prognose dieser Entität ausgewirkt. Nichtsdestotrotz können auch heute bereits Patienten mit Bauchspeicheldrüsenkrebs von erweiterter molekularer Diagnostik profitieren.

Schlüsselwörter

Präzisionsonkologie Molekulare Diagnostik Zielgerichtete Therapie Tumorerkrankungen Molekulare Pathologie 

Molecular characterization of pancreatic cancer

Therapeutic implications

Abstract

Background

Precision oncology has achieved significant successes in the treatment of many malignant diseases. Based on comprehensive molecular profiling the treatment reality of many tumors has been decisively changed and in part been revolutionized. Along the same lines, there is a growing body of knowledge with respect to the molecular pathology of pancreatic cancer. The aim of this article is to briefly outline potential therapeutic strategies to implement precision oncology in the treatment of pancreatic cancer.

Conclusion

While there is growing knowledge about the molecular pathology of pancreatic cancer, this knowledge has not been translated into a change in management or an improvement of the dismal prognosis of pancreatic cancer. Nevertheless, even today some patients with pancreatic cancer might profit from extended molecular diagnostics.

Keywords

Precision cancer medicine Molecular diagnostics Targeted therapies Tumor diseases Molecular pathology 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

C. B. Westphalen, K. Heinrich, S. Böck und V. Heinemann geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  • C. Benedikt Westphalen
    • 1
    Email author
  • Kathrin Heinrich
    • 1
  • Stefan Böck
    • 1
  • Volker Heinemann
    • 1
  1. 1.Medizinische Klinik und Poliklinik III, Klinikum der Universität München, Großhadern und Comprehensive Cancer Center MünchenLMUMünchenDeutschland

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